Risk factors for invasive fungal disease in critically ill adult patients: a systematic review

Table 6 Methodology and reporting assessment: statistical assessment

	Power				Risk factor selection^α				Statistical model^α
Article	Events	Variables	EPV	Were there ≥ 10 events per risk factor?	All Candidate risk factors used	Risk factors chosen based on previous literature/investigator choice	Risk factors chosen based on univariable analysis	Unclear	No selection: all variables kept in model	Backward elimination	Forward selection	Unclear
Agvald-Ohman et al., 2008 [28]	10	> 10	< 1	x				✓				✓
Blumberg et al., 2001 [29]	42	49	0.9	x				✓		✓
Borzotta & Beardsley, 1999 [34]	20	> 21	< 1	x			✓			✓
Chow et al., 2008 [30]	67^a 79^b	35	1.9^a 2.3^b	x			✓					✓
Ibàñez-Nolla et al., 2004 [31]	120	30	< 4	x				✓				✓
Jordà-Marcos et al., 2007 [26]	63	15	4.2	x			✓				✓
León et al., 2006 [27]	97	22	4.4	x			✓			✓
Michalopoulos et al., 2003 [36]	30	29	1.0	x				✓			✓
McKinnon et al., 2001 [32]	27	23	1.2	x			✓					✓
Ostrosky-Zeichner et al., 2007 [37]	88	27	3.3	x				✓			✓
Paphitou et al., 2005 [35]	36	> 49	< 0.8	x				✓				✓
Piarroux et al., 2004 [38]	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pittet et al., 1994 [33]	11	9	1.2	x			✓					✓

EPV = events per variable; ^aevents/EPV for outcomes in Candida albicans; ^bevents/EPV for outcomes in Candida non-albicans; α = most appropriate of the four options selected in each case; n/a = not applicable (evaluation of clinical decision rule, no risk factor analysis).

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