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Table 3 Clinical relevance of the NLRP3 gene polymorphisms in patients with major trauma

From: Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma

Polymorphic sites

Genotypes

Number of patients

Mean age ± SD

(years)

Sex

(M/F)

Mean ISS ± SD

Sepsis, n(%)

Mean MOD score ± SEM

 

GG

642

40.6 ± 13.8

513/129

22.5 ± 10.0

252 (39.3)

4.2 ± 0.1

rs2027432

GA

73

40.9 ± 12.9

60/13

22.4 ± 9.8

32 (43.8)

4.1 ± 0.4

 

AA

3

49.0 ± 26.1

3/0

21.7 ± 10.3

2 (66.7)

8.7 ± 1.2

P-value

      

a1

 

GG

454

40.5 ± 13.5

369/85

22.2 ± 9.9

173 (38.1)

4.0 ± 0.2

rs3738448

GT

231

40.9 ± 14.4

176/55

22.9 ± 10.2

95 (41.1)

4.3 ± 0.2

 

TT

20

40.7 ± 13.3

18/2

22.4 ± 10.0

11 (55)

4.4 ± 0.8

 

AA

398

40.2 ± 13.8

320/78

22.3 ± 9.8

175 (44.0)

4.3 ± 0.2

rs12048215

AG

267

40.5 ± 13.6

217/50

22.9 ± 10.5

97 (36.3)

4.1 ± 0.2

 

GG

53

44.7 ± 14.1

39/14

21.4 ± 8.0

14 (26.4)

3.7 ± 0.1

P-value

     

a2, b1

 
 

CC

193

39.6 ± 13.8

165/28

21.7 ± 9.3

76 (39.4)

4.0 ± 0.2

rs4612666

CT

380

40.6 ± 13.4

295/85

22.9 ± 10.6

156 (41.1)

4.2 ± 0.2

 

TT

138

42.4 ± 14.7

109/29

22.4 ± 9.2

49 (35.5)

4.0 ± 0.3

 

CC

251

40.1 ± 14.1

195/56

22.4 ± 9.4

111 (44.2)

4.2 ± 0.2

rs1539019

CA

349

40.4 ± 13.7

283/66

23.1 ± 10.1

129 (37.0)

4.3 ± 0.2

 

AA

118

40.0 ± 13.0

98/20

20.9 ± 10.5

46 (39.0)

3.9 ± 0.3

 

CC

246

40.5 ± 14.9

186/60

21.6 ± 9.1

99 (40.2)

3.9 ± 0.2

rs10754558

CG

354

40.6 ± 13.2

291/62

23.0 ± 10.3

134 (37.9)

4.4 ± 0.2

 

GG

114

40.3 ± 12.5

96/18

22.6 ± 10.7

51 (44.7)

3.9 ± 0.3

  1. ISS = Injury Severity Score; MOD score = Multiple Organ Dysfunction score. a = recessive effect (variant homozygotes versus heterozygotes + wild-type homozygotes); b = dominant effect (variant homozygotes + heterozygotes versus wild-type homozygotes) as analyzed by one-way analysis of variance. a1, P = 0.024; a2, P = 0.038; b1, P = 0.012.