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Table 4 Fluid management: anesthesiologists versus closed loop

From: Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study

 

No management

(1)

Anesthesiologist managed

(2)

Anesthesiologist, pressors; closed-loop, fluids

(3)

Closed-loop managed

(4)

Time window until the application of first bolus from start of hemorrhage (min)

-

21.5 ± 5.6a

15.6 ± 1.1

16.0 ± 1.3

Total fluid given (ml)

-

1,968 + 644a

2,875 ± 275

2,675 ± 244

Mean arterial pressure (mm Hg)

61 ± 6.9

76 ± 4.2

79 ± 2.0

79 + 1.1

Mean cardiac output (L/min)

3.8 ± 0.4

5.2 ± 0.6a

5.8 ± 0.2b

5.9 ± 0.2b

Minimum cardiac output (L/min)

1.4 ± 0.8

3.6 ± 1.3a

4.8 ± 0.5b

4.8 ± 0.4b

Final cardiac output (L/min)

1.7 ± 0.9

4.8 ± 1.5a

5.6 ± 0.5b

5.7 ± 0.4b

Cardiac output during case, coefficient of variance (%)

89 ± 29

36.7 ± 23a

16.6 ± 9b

16.3 ± 8b

  1. n = 20 in each group. Data are reported as mean ± standard deviation. aP < 0.05 versus groups 2, 3, and 4. bP < 0.05 versus groups 1 and 4.