No management (1) | Anesthesiologist managed (2) | Anesthesiologist, pressors; closed-loop, fluids (3) | Closed-loop managed (4) | |
---|---|---|---|---|
Time window until the application of first bolus from start of hemorrhage (min) | - | 21.5 ± 5.6a | 15.6 ± 1.1 | 16.0 ± 1.3 |
Total fluid given (ml) | - | 1,968 + 644a | 2,875 ± 275 | 2,675 ± 244 |
Mean arterial pressure (mm Hg) | 61 ± 6.9 | 76 ± 4.2 | 79 ± 2.0 | 79 + 1.1 |
Mean cardiac output (L/min) | 3.8 ± 0.4 | 5.2 ± 0.6a | 5.8 ± 0.2b | 5.9 ± 0.2b |
Minimum cardiac output (L/min) | 1.4 ± 0.8 | 3.6 ± 1.3a | 4.8 ± 0.5b | 4.8 ± 0.4b |
Final cardiac output (L/min) | 1.7 ± 0.9 | 4.8 ± 1.5a | 5.6 ± 0.5b | 5.7 ± 0.4b |
Cardiac output during case, coefficient of variance (%) | 89 ± 29 | 36.7 ± 23a | 16.6 ± 9b | 16.3 ± 8b |