Skip to main content

Table 3 Final hemodynamic parameters in Phase 1 groups

From: Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study

  No intervention (n= 20) Closed-loop management (n= 20) P value
Massive hemorrhage    
   Fluid given (ml) 300 ± 0 3,420 ± 117  
   HR (beats/min) 141 ± 29 76 ± 8 < 0.001
   MAP (mm Hg) 59 ± 26 91 ± 6 < 0.001
   CO (L/min) 3.2 ± 1.8 6.4 ± 0.9 < 0.001
Moderate hemorrhage    
   Fluid given (ml) 300 ± 0 1,543 ± 54  
   HR (beats/min) 119 ± 32 73 ± 9 < 0.001
   MAP (mm Hg) 76 ± 10 88 ± 7 < 0.005
   CO (L/min) 5.0 ± 1.1 6.9 ± 0.8 < 0.001
Mild hemorrhage    
   Fluid given (ml) 300 ± 0 653 ± 44  
   HR (beats/min) 77 ± 10 72 ± 9 0.08
   MAP (mm Hg) 85 ± 7 87 ± 8.8 0.3
   CO (L/min) 6.6 ± 1.0 6.5 ± 1.0 0.73
  1. Data are presented as mean ± SD. CO, cardiac output; HR, heart rate; MAP, mean arterial pressure.