Figure 1From: Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation studyRule-based component of the controller algorithm. The controller uses patient hemodynamic parameters (primarily pulse-pressure variation, but also cardiac output, mean arterial pressure, and heart rate) that are compared with the dataset and a probability of positive response assigned based on the population data. This probability and the hemodynamic data are then fed into the rule-based component of the controller. CO, Cardiac output.Back to article page