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Table 3 Validation of C-reactive protein levels and white blood cell counts for infectious complications during SE

From: Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus

CRP levels
(mg/L)
  Infections
during SE (n = 36)
No infections(n = 103) Sensitivity Specificity PPV NPV LR+ LR-
    SD or range   SD or range       
CRP on day 1 of SE mean 40.80 44.54 32.35 50.09 70.0% 53.4% 30.4% 85.9% 1.5 1.8
  median 28.35 0.6 - 178.8 7.60 0.3 - 225.5       
CRP on day 2 of SE mean 77.17 70.13 42.90 53.54 86.7% 37.9% 28.9% 90.7% 1.4 0.4
  median 55.20 0.6 - 245.0 22.00 0.5 - 233.5       
CRP on day 3 of SE mean 116.04 98.01 62.39 67.99 93.3% 60.2% 40.6% 96.9% 2.3 0.1
  median 92.35 1.0 - 383.8 36.95 1.2 - 256.7       
White blood cell levels
(x10 9 /L)
  Infections
during SE (n = 36)
No infections
(n = 103)
Sensitivity Specificity PPV NPV LR+ LR-
    SD or range   SD or range       
WBC on day 1 of SE mean 12.23 6.44 10.71 5.05 72.5% 51.5% 36.7% 82.8% 1.5 0.5
  median 10.50 2.8 - 26.4 10.00 1.2 - 32.7       
WBC on day 2 of SE mean 9.75 5.09 10.62 5.68 36.7% 55.3% 19.3% 75.0% 0.8 1.1
  median 9.45 1.6 - 29.7 9.80 1.0 - 34.4       
WBC on day 3 of SE mean 9.52 5.00 9.64 4.64 33.3% 63.1% 20.8% 76.5% 0.9 1.1
  median 8.85 3.0 - 26.0 8.40 0.8 - 23.3       
Association with infections during SE (Infections during SE vs. no infections during SE) (n = 160)
Marker Linear change with time OR* 95% CI p-value
CRP over time Change from day 1 to 3 (mg/L) 1.018 1.007-1.029 0.0012
WBC over time Change from day 1 to 3 (x109/L) 0.754 0.603-0.944 0.0137
  1. SD = standard deviation; SE = status epilepticus; CPR = cardiopulmonary resuscitation; CNS = central nervous system; CRP = C-reactive protein; WBC = white blood cells; PPV = positive predictive value; NPV = negative predictive value; LR+ = likelihood ratio positive; LR- = likelihood ratio negative