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Table 3 Validation of C-reactive protein levels and white blood cell counts for infectious complications during SE

From: Acute phase proteins and white blood cell levels for prediction of infectious complications in status epilepticus

CRP levels

(mg/L)

 

Infections

during SE (n = 36)

No infections(n = 103)

Sensitivity

Specificity

PPV

NPV

LR+

LR-

   

SD or range

 

SD or range

      

CRP on day 1 of SE

mean

40.80

44.54

32.35

50.09

70.0%

53.4%

30.4%

85.9%

1.5

1.8

 

median

28.35

0.6 - 178.8

7.60

0.3 - 225.5

      

CRP on day 2 of SE

mean

77.17

70.13

42.90

53.54

86.7%

37.9%

28.9%

90.7%

1.4

0.4

 

median

55.20

0.6 - 245.0

22.00

0.5 - 233.5

      

CRP on day 3 of SE

mean

116.04

98.01

62.39

67.99

93.3%

60.2%

40.6%

96.9%

2.3

0.1

 

median

92.35

1.0 - 383.8

36.95

1.2 - 256.7

      

White blood cell levels

(x10 9 /L)

 

Infections

during SE (n = 36)

No infections

(n = 103)

Sensitivity

Specificity

PPV

NPV

LR+

LR-

   

SD or range

 

SD or range

      

WBC on day 1 of SE

mean

12.23

6.44

10.71

5.05

72.5%

51.5%

36.7%

82.8%

1.5

0.5

 

median

10.50

2.8 - 26.4

10.00

1.2 - 32.7

      

WBC on day 2 of SE

mean

9.75

5.09

10.62

5.68

36.7%

55.3%

19.3%

75.0%

0.8

1.1

 

median

9.45

1.6 - 29.7

9.80

1.0 - 34.4

      

WBC on day 3 of SE

mean

9.52

5.00

9.64

4.64

33.3%

63.1%

20.8%

76.5%

0.9

1.1

 

median

8.85

3.0 - 26.0

8.40

0.8 - 23.3

      

Association with infections during SE (Infections during SE vs. no infections during SE) (n = 160)

Marker

Linear change with time

OR*

95% CI

p-value

CRP over time

Change from day 1 to 3 (mg/L)

1.018

1.007-1.029

0.0012

WBC over time

Change from day 1 to 3 (x109/L)

0.754

0.603-0.944

0.0137

  1. SD = standard deviation; SE = status epilepticus; CPR = cardiopulmonary resuscitation; CNS = central nervous system; CRP = C-reactive protein; WBC = white blood cells; PPV = positive predictive value; NPV = negative predictive value; LR+ = likelihood ratio positive; LR- = likelihood ratio negative