Skip to main content

Table 6 Variables predictive of SSAKI in selected major adult trials

From: Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray

Study Criteria SSAKI (%) Variable outcome
PROWESS [39] Pre-infusion log IL-6, APACHE II score 127/547 (23.2) Hazard ratio = 1.16 (95% CI = 1.07 to 1.26); P <0.001
    Hazard ratio = 1.23 (95% CI = 1.09 to 1.39); P <0.001
NORASEPT II [54] Plasma IL-6 112/537 (20) Not significant
  Plasma TNFα   Not significant
  Soluble TNFα receptor type I   Higher in SSAKI; P <0.0001
  Soluble TNFα receptor type II   Higher in SSAKI; P <0.0001
PICARD [40] Plasma TNFα 34/97 (35) Higher in patients with SSAKI (P = 0.001) than those without sepsis
  Plasma IL-6   Not significant
Hoste and colleagues [55] APACHE II score 30/185 (16.2) APACHE II score higher (P = 0.002)
  pH <7.35   OR for developing ARF = 6.25 (95% CI = 1.92 to 20.4); P = 0.002
  Serum creatinine >1 mg/dl   OR for developing ARF = 7.56 (95% CI = 2.16 to 26.5); P = 0.002
Martensson and colleagues [56] Peak serum NGAL 18/45 (40) Not significant in SSAKI vs. septic shock without AKI
  Peak urine NGAL   Higher in SSAKI than septic shock without AKI (P <0.05)
Shapiro and colleagues [43] Emergency room plasma NGAL 24/661 (3.6) NGAL >150: sensitivity = 96% and specificity = 51%
de Geus and colleagues [42] Serum NGAL 171/632 (27) OR of developing ARF = 1.7
  Urine NGAL   OR of developing ARF = 1.42
  Sepsis   OR of developing ARF = 9.15
  1. AKI, acute kidney injury; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; NGAL, neutrophil gelatinase-associated lipocalin; NORASEPT, North American Study for the Safety and Efficacy of Murine Monoclonal Antibody to Tumor Necrosis Factor Alpha for the Treatment of Septic Shock; OR, odds ratio; PICARD, Program to Improve Care in Acute Renal Disease; PROWESS, Prospective Recombinant Activated Protein C Worldwide Evaluation in Severe Sepsis; SSAKI, sepsis-shock-associated acute kidney injury; TNF, tumor necrosis factor.