Serum matrix metalloproteinase-8 and elastase-2 levels in patients with and without sepsis-shock-associated acute kidney injury. Serum matrix metalloproteinase-8 (MMP-8) and elastase-2 levels are higher in patients with sepsis-shock-associated acute kidney injury (SSAKI) than patients without SSAKI. Patients with SSAKI (n = 132) were compared with patients without SSAKI (n = 18). Serum samples were obtained within 24 hours of admission to the pediatric ICU with septic shock and were drawn in parallel with RNA samples. Medians and interquartile ranges for the targets of interest for no SSAKI versus SSAKI: MMP-8, 26 (9 to 49) versus 40 (20 to 98), P = 0.029; and neutrophil elastase-2, 340 (9 to 571) and 574 (444 to 911), P = 0.01 (rank-sum test).