Table 3 Blood pressure, laboratory values, end-organ damage and outcomes (in-hospital)
Variables | All patients (n= 791) | Enrolment setting | ||
|---|---|---|---|---|
ED (n= 180) | ICU (n= 382) | Perioperative (n= 229) | ||
Median blood pressure, mmHg (IQR) | ||||
Qualifying SBP | 166 (141 to 190) | 200 (174 to 220) | 160 (138 to 180) | 160 (140 to 180) |
Qualifying DBP | 80 (68 to 95) | 100 (90 to 110) | 73 (64 to 85) | 80 (68 to 90) |
Median time from qualifying BP to initiation of IV antihypertensive therapy, minutes (IQR) | 5.0 (2.0 to 17) | 20 (5.0 to 30) | 5.0 (1.0 to 15) | 5.0 (1.0 to 5.0) |
Median time from IV initiation to 10% decrease in SBP, minutes (IQR) | 28 (11 to 60) | 31 (18 to 87) | 30 (12 to 70) | 18 (8.0 to 43) |
Median laboratory values (IQR) | ||||
Peak troponin | 0.03 (0.01 to 0.23) | 0.03 (0.01 to 0.12) | 0.04 (0.01 to 0.33) | 0.03 (0.01 to 0.23) |
Peak creatine kinase-MB | 33 (9.4 to 88) | 5.1 (3.8 to 78) | 50 (31 to 152) | 38 (24 to 79) |
Peak NT-proBNP | 910 (295 to 2, 240) | 1, 672 (429 to 2, 637) | 1, 451 (428 to 2, 709) | 359 (242 to 970) |
Peak BNP | 99 (82 to 132) | 116 (91 to 146) | 20 (20 to 20) | n/a |
Initial creatinine, μmol/L | 89 (72 to 113) | 94 (78 to 125) | 91 (74 to 116) | 83 (69 to 102) |
Peak creatinine, μmol/L | 103 (82 to 146) | 119 (99 to 222) | 107 (84 to 151) | 92 (73 to 122) |
End-organ injurya, n (%) | ||||
Acute coronary syndrome (new) | 25 (3.2) | 22 (12) | 2 (0.5) | 1 (0.4) |
Previous worsened | 10 (1.3) | 8 (4.4) | 2 (0.5) | 0 (0.0) |
Acute LV dysfunction/pulmonary oedema (new) | 28 (3.5) | 19 (11) | 7 (1.8) | 2 (0.9) |
Previous worsened | 20 (2.5) | 16 (8.9) | 4 (1.1) | 0 (0.0) |
Aortic dissection (new) | 5 (0.6) | 2 (1.1) | 3 (0.8) | 0 (0.0) |
Previous worsened | 2 (0.3) | 1 (0.6) | 1 (0.3) | 0 (0.0) |
Encephalopathy (new) | 22 (2.8) | 8 (4.4) | 11 (2.9) | 3 (1.3) |
Previous worsened | 2 (0.3) | 1 (0.6) | 0 (0.0) | 1 (0.4) |
Acute kidney failure (new) | 36 (4.6) | 8 (4.4) | 23 (6.0) | 5 (2.2) |
Previous worsened | 19 (2.4) | 5 (2.8) | 12 (3.1) | 2 (0.9) |
Stroke (new) | 13 (1.6) | 8 (4.4) | 5 (1.3) | 0 (0.0) |
Previous worsened | 7 (0.9) | 3 (1.7) | 2 (0.6) | 2 (0.9) |
Outcomes n (%) | ||||
ICU admission | 114 (14) | 17 (9.4) | 19 (5.0)b | 78 (34) |
Hypertension relapse | 104 (13) | 14 (7.8) | 55 (14) | 35 (15) |