Table 1 Randomized trials of shorter- versus longer-duration antibiotic therapy in bacteremia or syndromes commonly causing bacteremia.
From: Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis
Author | Syndrome | Number screened (number randomly assigned) | Population | Antibiotic | Short arm, days | Long arm, days | Day of random assignment | Random assignment/Concealment | Blinding/Placebo | Patients with bacteremia |
|---|---|---|---|---|---|---|---|---|---|---|
Chowdhary et al. [26] | Bacteremia | 229 (69) | Hospitalized neonates | Culture-directed | 7 | 14 | 7 | Computer-generated/Yes | Yes/No | Included |
Basoli et al. [27] | Peritonitis | 111 (90) | Secondary peritonitis | Ertapenem | 3 | 5-14 | 3 | Unclear/Unclear | Yes/Yes | Unclear |
Runyon et al. [28] | Peritonitis | 140 (100) | Hospitalized adults; SBP | Cefotaxime | 5 | 10 | 1 | Unclear/No | No/No | Included |
Chaudhry et al. [29] | Peritonitis | 60 (50) | Hospitalized adults; SBP | Cefoperazone | 5 | 10 | 1 | Unclear/No | No/No | Included |
Hepburn et al. [49] | SSTI | 169 (87) | Outpatient adults | Levofloxacin | 5 | 10 | 5 | Computer-generated/Yes | Yes/Yes | Excluded |
De Gier et al. [43] | Pyelonephritis | N/A (54) | Hospitalized adults; complicated UTI | Fleroxacin | 7 | 14 | 1 | Unclear/Unclear | Unclear/No | Unclear |
Stamm et al. [44] | Pyelonephritis | 98 (60) | Outpatient adult women | Ampicillin or TMP/SMX | 14 | 42 | 1 | Random number table/No | No/No | Unclear |
Gleckman et al. [45] | Pyelonephritis | N/A (54) | Hospitalized adult women | Gentamicin/tobramycin; ampicillin, TMP/SMX, cephalexin | 10 | 21 | 1 | Random number table/No | No/No | Unclear |
Pylkkanen et al. [46] | Pyelonephritis | 271 (149) | Infants and children | Sulfafurazole | 10 | 42 | 1 | Unclear/No | No/No | Unclear |
Jernelius et al. [47] | Pyelonephritis | N/A (77) | Outpatient and hospitalized adults | Pivampicillin and pivmecillinam | 7 | 21 | 1 | Computer-generated/Yes | Yes/Yes | Included |
Cheng et al. [48] | Pyelonephritis | N/A (80) | Hospitalized children | Acc. to culture | 14 | 21 | 1 | Serial entry/Unclear | Unclear/No | Included |
Engle et al. [30] | Pneumonia | 51 (26) | Hospitalized neonates | Ampicillin and gentamicin | 2 | 4 | 2 | Unclear/Unclear | Unclear/No | Included |
Engle et al. [31] | Pneumonia | 212 (73) | Hospitalized neonates | Ampicillin and gentamicin | 4 | 7 | 2 | Unclear/Yes | Unclear/No | Included |
ISCAP [33] | Pneumonia | N/A (2,188) | Outpatient children 2 to 59 months | Amoxicillin | 3 | 5 | 1 | Unclear/Yes | Yes/Yes | Unclear |
MASCOT [34] | Pneumonia | N/A (2,000) | Outpatient children 2 to 59 months | Amoxicillin | 3 | 5 | 1 | Computer-generated/Yes | Yes/Yes | Unclear |
Vuori-Holopainen et al. [32] | Pneumonia | 178 (72) | Hospitalized children 3 months to 15 years | Penicillin or cefuroxime | 4 | 7 | 1 | Computer-generated/No | No/No | Included |
Tellier et al. [36] | Pneumonia | 581 (575) | Outpatient and hospitalized adults | Telithromycin | 5 | 7 | 1 | Unclear/Yes | Yes/Yes | Included |
File et al. [35] | Pneumonia | N/A (512) | Outpatient adults | Gemifloxacin | 5 | 7 | 1 | Unclear/Unclear | Yes/Unclear | Included |
Dunbar et al. [37] | Pneumonia | 2,521 (530) | Outpatient and hospitalized adults | Levofloxacin | 5 | 10 | 1 | Unclear/Yes | Yes/Yes | Included |
Leophonte et al. [39] | Pneumonia | N/A (244) | Hospitalized adults | Ceftriaxone | 5 | 10 | 1 | Unclear/Yes | Yes/Yes | Included |
Siegel et al. [38] | Pneumonia | N/A (52) | Hospitalized adults | Cefuroxime | 7 | 10 | 1 | Computer-generated/Yes | Yes/Yes | Included |
El Moussaoui et al. [40] | Pneumonia | 186 (121) | Hospitalized adults | Amoxicillin | 3 | 8 | 3 | Unclear/Yes | Yes/Yes | Included |
Chastre et al. [42] | Pneumonia | 1,171 (402) | Hospitalized adults | Culture-directed | 8 | 15 | 3 | Computer-generated/Yes | Yes/No | Included |
Fekih Hassen et al. [41] | Pneumonia | 39 (30) | Hospitalized adults | Culture-directed | 7 | 10 | 2 | Random number table/No | No/No | Unclear |