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Table 1 Randomized trials of shorter- versus longer-duration antibiotic therapy in bacteremia or syndromes commonly causing bacteremia.

From: Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis

Author Syndrome Number screened (number randomly assigned) Population Antibiotic Short arm, days Long arm, days Day of random assignment Random assignment/Concealment Blinding/Placebo Patients with bacteremia
Chowdhary et al. [26] Bacteremia 229 (69) Hospitalized neonates Culture-directed 7 14 7 Computer-generated/Yes Yes/No Included
Basoli et al. [27] Peritonitis 111 (90) Secondary peritonitis Ertapenem 3 5-14 3 Unclear/Unclear Yes/Yes Unclear
Runyon et al. [28] Peritonitis 140 (100) Hospitalized adults; SBP Cefotaxime 5 10 1 Unclear/No No/No Included
Chaudhry et al. [29] Peritonitis 60 (50) Hospitalized adults; SBP Cefoperazone 5 10 1 Unclear/No No/No Included
Hepburn et al. [49] SSTI 169 (87) Outpatient adults Levofloxacin 5 10 5 Computer-generated/Yes Yes/Yes Excluded
De Gier et al. [43] Pyelonephritis N/A (54) Hospitalized adults; complicated UTI Fleroxacin 7 14 1 Unclear/Unclear Unclear/No Unclear
Stamm et al. [44] Pyelonephritis 98 (60) Outpatient adult women Ampicillin or TMP/SMX 14 42 1 Random number table/No No/No Unclear
Gleckman et al. [45] Pyelonephritis N/A (54) Hospitalized adult women Gentamicin/tobramycin; ampicillin, TMP/SMX, cephalexin 10 21 1 Random number table/No No/No Unclear
Pylkkanen et al. [46] Pyelonephritis 271 (149) Infants and children Sulfafurazole 10 42 1 Unclear/No No/No Unclear
Jernelius et al. [47] Pyelonephritis N/A (77) Outpatient and hospitalized adults Pivampicillin and pivmecillinam 7 21 1 Computer-generated/Yes Yes/Yes Included
Cheng et al. [48] Pyelonephritis N/A (80) Hospitalized children Acc. to culture 14 21 1 Serial entry/Unclear Unclear/No Included
Engle et al. [30] Pneumonia 51 (26) Hospitalized neonates Ampicillin and gentamicin 2 4 2 Unclear/Unclear Unclear/No Included
Engle et al. [31] Pneumonia 212 (73) Hospitalized neonates Ampicillin and gentamicin 4 7 2 Unclear/Yes Unclear/No Included
ISCAP [33] Pneumonia N/A (2,188) Outpatient children 2 to 59 months Amoxicillin 3 5 1 Unclear/Yes Yes/Yes Unclear
MASCOT [34] Pneumonia N/A (2,000) Outpatient children 2 to 59 months Amoxicillin 3 5 1 Computer-generated/Yes Yes/Yes Unclear
Vuori-Holopainen et al. [32] Pneumonia 178 (72) Hospitalized children 3 months to 15 years Penicillin or cefuroxime 4 7 1 Computer-generated/No No/No Included
Tellier et al. [36] Pneumonia 581 (575) Outpatient and hospitalized adults Telithromycin 5 7 1 Unclear/Yes Yes/Yes Included
File et al. [35] Pneumonia N/A (512) Outpatient adults Gemifloxacin 5 7 1 Unclear/Unclear Yes/Unclear Included
Dunbar et al. [37] Pneumonia 2,521 (530) Outpatient and hospitalized adults Levofloxacin 5 10 1 Unclear/Yes Yes/Yes Included
Leophonte et al. [39] Pneumonia N/A (244) Hospitalized adults Ceftriaxone 5 10 1 Unclear/Yes Yes/Yes Included
Siegel et al. [38] Pneumonia N/A (52) Hospitalized adults Cefuroxime 7 10 1 Computer-generated/Yes Yes/Yes Included
El Moussaoui et al. [40] Pneumonia 186 (121) Hospitalized adults Amoxicillin 3 8 3 Unclear/Yes Yes/Yes Included
Chastre et al. [42] Pneumonia 1,171 (402) Hospitalized adults Culture-directed 8 15 3 Computer-generated/Yes Yes/No Included
Fekih Hassen et al. [41] Pneumonia 39 (30) Hospitalized adults Culture-directed 7 10 2 Random number table/No No/No Unclear
  1. ISCAP, IndiaClen Short Course Amoxicillin Pneumonia; MASCOT, Multicentre Amoxicillin Short Course Therapy; N/A, not applicable; SBP, spontaneous bacterial peritonitis; SSTI, skin and soft tissue infection; TMP/SMX, trimethoprim/sulfamethoxazole; UTI, urinary tract infection.