Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU

Table 3 Correlations with liver stiffness measurements

			Liver stiffness measurements
	Admission		Day 3		Day 7
	r	P	r	P	r	P
Hepatic organ function
*Liver synthesis*
F VII	-0.365	0.002	-0.282	0.034	-	n.s.
PCHE	-0.487	< 0.001	-0.376	0.009	-	n.s.
INR	0.399	< 0.001	-	n.s.	-	n.s.
AT III	-0.299	0.012	-	n.s.	-	n.s.
*Cholestasis*
bilirubin	0.489	< 0.001	-	n.s.	0.415	0.008
gamma-GT	0.330	0.003	-	n.s.	0.343	0.030
AP	0.355	0.005	-	n.s.	-	n.s.
*Liver fibrosis*
hyaluronan	0.415	0.001	-	n.s.	-	n.s.
Non-hepatic organ function
*Kidney*
cystatin C	-	n.s.	0.273	0.044	0.367	0.030
cystatin C GFR	-	n.s.	-0.276	0.042	-0.377	0.026
*Lung*
ventilation time	-	n.s.	0.332	0.011	0.573	< 0.001
PiP	0.423	0.001	-	n.s.	-	n.s.
PEEP	0.413	0.001	-	n.s.	-	n.s.
*Circulation*
noradrenalin dose	0.286	0.013	-	n.s.	0.349	0.037
NT-proBNP	-	n.s.	0.284	0.032	0.478	0.002
CVP	-	n.s.	-	n.s.	0.553	0.003
net fluid balance	-	n.s.	-	n.s.	0.332	0.045
Overall disease severity
APACHE II score	0.350	0.007	0.304	0.040	0.413	0.023
SOFA score	0.324	0.016	-	n.s.	0.562	0.003

r, correlation coefficient; P, P-value (r and P-values by Spearman rank correlation); only significant correlations are shown. Abbreviations are: AP, alkaline phosphatase; APACHE, Acute Physiology and Chronic Health Evaluation; AT III, antithrombin III; CRP, C-reactive protein; CVP, central venous pressure; F VII, factor VII; gamma-GT, gamma-glutamyl-transferase; GFR, glomerular filtration rate; ICU, intensive care unit; INR, international normalized ratio; PiP, positive inspiratory pressure; PCHE, pseudocholinesterase; PEEP, positive endexpiratory pressure; SOFA, sequential organ failure assessment

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