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Table 4 Coagulation parameters and their prediction of massive transfusion (MT)

From: FIBTEM provides early prediction of massive transfusion in trauma

  ROC-AUC (95% CI) Optimum threshold (for best sensitivity and specificity) Sensitivity (95% CI) Specificity (95% CI)
FIBTEM MCF 0.84 (0.79 to 0.88) ≤7 mm 77.5 (66.8 to 86.1) 74.9 (68.9 to 80.3)
FIBTEM A10 0.83 (0.78 to 0.87) ≤4 mm 63.3 (51.7 to 73.9) 83.2 (77.8 to 87.7)
EXTEM CT 0.71 (0.66 to 0.76) ≤72 s 76.3 (65.2 to 85.3) 59.4 (52.7 to 65.8)
EXTEM CFT 0.74 (0.68 to 0.79) ≤147 s 64.5 (52.7 to 75.1) 75.1 (69.0 to 80.6)
EXTEM MCF 0.76 (0.71 to 0.81) ≤52 mm 67.1 (55.4 to 77.5) 71.2 (64.8 to 77.0)
INTEM CT 0.71 (0.65 to 0.76) ≤167 s 65.3 (53.1 to 76.1) 75.5 (69.3 to 80.9)
INTEM CFT 0.78 (0.73 to 0.82) ≤111 s 75.0 (63.4 to 84.5) 67.3 (60.7 to 73.4)
INTEM MCF 0.78 (0.73 to 0.83) ≤51 mm 61.6 (49.5 to 72.8) 80.4 (74.5 to 85.3)
Platelet count 0.70 (0.65 to 0.75) ≤161 × 103/μl 62.0 (50.4 to 72.7) 73.8 (67.8 to 79.3)
Quick value 0.87 (0.83 to 0.90) ≤60% 84.8 (75.0 to 91.9) 82.1 (76.6 to 86.8)
aPTT 0.85 (0.81 to 0.89) ≤35.2 s 71.6 (59.9 to 81.5) 87.8 (82.8 to 91.7)
Fibrinogen concentration 0.83 (0.78 to 0.87) ≤148 mg/dL 84.2 (74.0 to 91.6) 68.3 (61.8 to 74.3)
Hemoglobin 0.87 (0.83 to 0.91) ≤10.1 g/dL 77.5 (66.8 to 86.1) 84.5 (79.3 to 88.9)
Base deficit 0.76 (0.76 to 0.86) ≤6.3 69.6 (57.3 to 80.1) 79.8 (73.3 to 85.3)
pH 0.76 (0.70 to 0.81) ≤7.276 62.3 (49.8 to 73.7) 80.0 (73.6 to 85.4)
Lactate 0.74 (0.69 to 0.79) ≤4.18 mmol/L 54.9 (42.7 to 66.8) 88.0 (82.9 to 92.0)
  1. A10, clot amplitude 10 minutes after CT; aPTT, activated partial thromboplastin time; CFT, clot formation time; CI, confidence interval; CT, clotting time; EXTEM, extrinsically activated thromboelastometric test; FIBTEM, extrinsically activated thromboelastometric test with cytochalasin D; INTEM, intrinsically activated thromboelastometric test; MCF, maximum clot firmness; ROC-AUC, area under the receiver operating characteristic curve.