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Figure 5 | Critical Care

Figure 5

From: The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

Figure 5

Vasculotide (VT) improves survival of septic mice. Kaplan-Meier curves with log-rank testing show the effect of VT on survival in polymicrobial sepsis induced by cecal ligation and puncture (CLP). (A) Mice were pretreated with different dosages (50, 200, or 500 ng) of VT or phosphate-buffered saline (PBS) intraperitoneally (control) at 16 hours and 1 hour prior to CLP and at 24 hours and 48 hours afterward. (B) Mice were subjected to CLP first and then treated with 200 ng of VT or PBS intraperitoneally at 2, 24, and 48 hours after CLP. Sham animals underwent the same procedure as CLP mice except for CLP and were treated with control buffer (PBS). CI, confidence interval; HR, hazard ratio.

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