Table 2 Effects of BNP on hemodynamics, renal function, and other parameters in patients undergoing cardiovascular surgery
Author, year, journal, country and study type | Patient group | Surgical procedure and dose of BNP | Effects of BNP on hemodynamics, renal function, and other parameters | |
|---|---|---|---|---|
BNP(n) | Control(n) | |||
Mentzer RM, et al. [28], 2007 J Am Coll Cardiol, USA, RCT | 137 | 135 | CABG on CPB, LVEF ≦ 40%, BNP 0.01 μg/kg/min, after anesthesia for 24-96 hrs | PAP (NS), urine output during the initial 24 hrs (BNP group, 2926 ± 1179 ml vs. Control group 2350 ± 1066 ml, P < 0.001), peak increase in SCr (BNP group, 0.15 vs. Control group, 0.34, P < 0.001), max decrease in GFR (BNP group, -10.8 ml/min/1.73 m2 vs. Control group, -17.2 ml/min/1.73 m2, P= 0.001), length of hospital stay↓, 180-day mortality↓ |
Chen HH, et al. [29], 2007 Circulation, USA RCT | 20 | 20 | Cardiac surgery on CPB, Ccr < 60 ml/min, BNP 0.005 μg/kg/min, after anesthesia for 24 hrs | Ccr↑, plasma cystatin↓, plasma BNP↑, plasma cGMP↑, aldosterone↓ |
Beaver TM, et al. [31], 2008 J Card Surg, USA RCT | 9 | 10 | Maze and mitral valve surgery, BNP 0.01 μg/kg/min, 3 hrs after CPB for 72 hrs | Urine output (NS), plasma ANP↓, furosemide doses (NS), time to extubation (NS), PaO2/FIO2 at 48 hrs (NS) |
Ejaz AA, et al. [30], 2009 J Thorac Cardiovasc Surg, USA RCT | 45 | 49 | High-risk cardiac surgery, BNP 0.01 μg/kg/min, before surgery→for 5 days | SCr ↓, GFR↑, incidence of AKI ↓, incidence of RRT (NS), all cause of mortality through day 21 (NS), length of hospital stay (NS) |