Author, year, journal, country and study type | Patient group | Surgical procedure and dose of ANP | Effects of ANP on hemodynamics, renal function, and other parameters | |
---|---|---|---|---|
 | ANP (n) | Control (n) |  |  |
Bergman A, et al. [22], 1996 J Cardiothorac Vasc Anesth, Sweden, RCT | 15 | 15 | Elective CABG on CPB, normal renal function ANP 7.5 pMol/kg/min, after operation for 3 hrs, | MAP→, HR→, PCWP→, RAP→, CI↓ Urine output↑, inulin clearance↑, FF↑, FENa↑ |
Hayashida N, et al. [34], 2000 Ann ThoracSurg, Japan, RCT | 9 | 9 | Elective mitral valve surgery on CPB ANP 0.05 μg/kg/min, after initiation of CPB for 6 hrs | PCWP↓, RAP↓, SVR↓, CI↑, Urine output↑, FENa↑, plasma cGMP↑, plasma BNP↓, |
Sezai A, et al. [21], 2000 Ann Thorac Surg, Japan, RCT | 20 | 20 | Elective CABG on CPB. ANP (SBP > 120 mmHg,0.05 μg/kg/min; SBP ≤ 120 mmHg, 0.03 μg/kg/min), after initiation of CPB for 24 hrs →0.02 μg/kg/min for 4 hrs, | CVP↓, SVRI↓, PVRI↓, plasma cGMP↑, Urine output↑, GFR↑, renin↓, angiotensin II↓, aldosterone↓, pleural effusion↓, furosemide↓ |
Hayashi Y, et al.[32], 2003 ASAIO Journal, Japan, RCT | 14 | 16 | Selective open heart operation on CPB ANP 0.025 μg/kg/min, after CPB for 72 hrs, | CVP↓, MPAP↓, PCWP↓, CI↑, furosemide↓, KCL↓, renin↓, aldosterone↓ |
Swärd K, et al. [25], 2004 Crit Care Med, Sweden RCT | 29 | 30 | Cardiac surgery, preoperative normal renal function, SCr > 50%↑, ANP 50 ng/kg/min→SCr decreased below the trigger value or RRT | Ccr↑, incidence of renal RRT on day 21 (ANP group 21% versus Control group 47%)↓ RRT-free survival at day 21↑ |
Sezai A, et al. [23], 2007 Circ J, Japan, RCT | 63 | 61 | Emergent CABG on CPB ANP 0.02 μg/kg/min at the start of CPB→0.01 μg/kg/min for 12 hrs | Peak CK-MB↓, arrhythmias↓, plasma BNP↓, furosemide↓, KCL↓ |
Izumi K, et al. [35], 2008 Ann Thorac Cardiovasc Surg, Japan, RCT | 10 | 8 | Elective cardiac surgery on CPB, SCr ≥ 1.2 mg/dl ANP 0.02 μg/kg/min, for 5 days or more | Urine output↑, SCr↓, Ccr↑, urinary NAG↓ |
Mitaka C, et al.[24], 2008 Crit Care Med, Japan RCT | 20 | 20 | Elective abdominal aortic aneurysm repair, SCr < 3 mg/dl ANP 0.01-0.05 μg/kg/min, before aortic cross clamping →for 48 hrs | Urine output↑, SCr↓, Ccr↑, BUN↓, urinary NAG/Cr↓, plasma ANP ↑, plasma BNP ↓, furosemide↓ |
Sumi K, et al. [33], 2008 J Cardiothorac Vas Anesth, Japan, RCT | 30 | 15 | Infrarenal abdominal aortic aneurysmectomy ANP 0.02 and 0.05 μg/kg/min, respectively, 5 min after aortic clamping→end of operation | MAP→, MPAP↓, PVRI↓, SVRI→ |
Sezai A, et al. [26], 2009 J Am Coll Cardiol, Japan RCT | 251 | 253 | Elective CABG on CPB, SCr < 1.3 mg/dl, Ccr ≥ 80 ml/min, ANP 0.02 μg/kg/min, at the start of CPB→0.01 μg/kg/min for 12 hrs | SCr↓, Ccr↑, SCr > 2.0 mg/dl (ANP group; n = 1, Control group; n = 8), RRT (ANP group; n = 0, Control group;n = 4) |
Sezai A, et al. [27], 2010 J Am Coll Cardiol, Japan RCT | 68 | 65 | Cardiac surgery on CPB, LVEF ≤ 35%, ANP 0.02 μg/kg/min, at the start of CPB→0.01 μg/kg/min for 12 hrs | LVEF↑, eGFR↑, SCr↓, plasma BNP↓, arrhythmias↓, mortality (NS), cardiac death-free rate at 5 or 8 years (ANP group; 98.5%, control group; 85.5%) |