Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients

Table 1 Characteristics of 13 intensive care patients

	Patient number
Variable	1	2	3	4	5	6	7	8	9	10	11	12	13	Mean	CV (%)
Weight (kg)	80	90	120	56	85	90	60	60	85	105	110	80	100	86.2	22.8
Age (years)	75	69	50	18	59	53	82	77	74	42	57	56	35	57.4	32.1
SAPS II	48	68	38	34	39	40	47	47	73	42	55	29	22	44.8	31.9
Bilirubin (μmol/L)	40	11	8	14	4	109	10	5	91	17	-	12	15	16.1^a	138
Creatinine (μmol/L)	79	179	186	45	163	112	175	44	156	97	-	77	72	103^a	56.2
Day from ICU admission	1.1	1.1	1.1	2.7	1.1	1.1	3.6	2.5	1.8	1.3	1.5	4.9	0.9	1.6^a	58.3
Vasopressors	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Midazolam (M) or propofol (P) rate (mg/kg/h)	-	0.1 (M)	2.3 (P)	3.8 (P)	1.9 (P)	-	3.2 (P)	1.3 (P)	1.7 (P)	0.1 (P)^b	2.9 (P)	0.1 (P)^b	1.5 (P)^b

Bilirubin and creatinine values refer to the highest value during dexmedetomidine infusion. Day from ICU admission refers to the day dexmedetomidine infusion was commenced. Vasopressors indicate whether the patient received vasoactive drugs before dexmedetomidine infusion. Midazolam or propofol rate, infusion rate before the start of dexmedetomidine infusion; CV, coefficient of variation; SAPS II, Simplified Acute Physiology Score; ^ageometric mean (backtransformed mean of the values on the logarithmic scale); ^bintravenous boluses.

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