Table 4 Renal effects of sepsis in pigs with and without acute kidney injury: comparison of sepsis models

Creatinine (μmol/L)

AKI-INF

95 (84-114)

92 (88-148)

105 (85-168)

150 (134-180)^ab

AKI-PERIT

98 (93-105)

107 (97-128)

129 (112-158)^c

131 (129-166)^ac

NONAKI-INF

106 (97-120)

100 (95-107)

102 (95-110)

109 (95-117)

NONAKI-PERIT

91 (84-91)

81 (78-96)

81 (77-91)

89 (84-94)

Renal vascular resistance (mm Hg/L/min)

AKI-INF

359 (235-635)

373 (288-700)

576 (273-1,161)

2,433 (1061-2,727)^a

AKI-PERIT

376 (302-459)

448 (280-637)

516 (236-821)

464 (404-1,425)

NONAKI-INF

471 (352-539)

388 (341-503)

415 (315-556)

355 (325-779)

NONAKI-PERIT

500 (431-541)

386 (320-407)

302 (273-340)^a

383 (339-438)

Renal-to-systemic vascular resistance ratio

AKI-INF

14 (11-17)

21 (13-32)

28 (17-58)

94 (49-170)^a

AKI-PERIT

12 (10-14)

25 (14-59)

39 (20-59)^a

38 (20-143)^a

NONAKI-INF

15 (14-19)

18 (16-35)

23 (16-40)

30 (19-63)^a

NONAKI-PERIT

16 (14-16)

18 (13-21)

16 (15-17)

24 (18-48)

Renal flow (ml/min/kg)

AKI-INF

6 (6-11)

6 (3-8)

4 (2-7)

1 (1-2)^a

AKI-PERIT

7 (5-8)

4 (3-5)

4 (2-6)

3 (1-4)^a

NONAKI-INF

5 (4-7)

4 (3-5)

5 (3-5)

4 (2-5)

NONAKI-PERIT

6 (5-6)

7 (6-8)

7 (7-9)^a

6 (4-6)

Renal cortical microcirculation (laser Doppler flowmetry) (% of baseline value)

AKI-INF

100 (100-100)

70 (57-105)

67 (55-97)

35 (25-51)^a

AKI-PERIT

100 (100-100)

59 (36-72)^a

61 (41-85)

57 (32-75)^a

NONAKI-INF

100 (100-100)

63 (53-111)

64 (52-101)

65 (47-92)

NONAKI-PERIT

100 (100-100)

88 (70-99)

75 (62-111)

59 (49-85)^a

Diuresis (ml/kg/h)

AKI-INF

1.7 (1-2.7)

2.7 (2.2-8)

4.8 (1.8-8.1)

1.1 (0.1-3.8)

AKI-PERIT

1.5 (1.3-1.9)

1.8 (1.5-2.3)

1.6 (0.9-2.1)

0.6 (0.2-0.9)^ac

NONAKI-INF

2.2 (1.3-2.5)

4.5 (3.8-5.5)^a

4.2 (1.7-5.4)

1.3 (1-2.3)

NONAKI-PERIT

1.6 (1.3-2.4)

2.3 (2-4.8)

3.9 (2.9-6.5)

1.7 (1.5-3.6)

TNF-α (pg/g of protein)

AKI-INF

2 (2-3)

8 (6-19)^a

14 (12-31)^a

25 (20-42)^a

AKI-PERIT

1 (1-3)

10 (5-16)

18 (5-30)^a

18 (5-105)^a

NONAKI-INF

2 (1-3)

4 (4-5)

18 (10-22)^a

7 (6-15)^a

NONAKI-PERIT

1 (1-1)

3 (2-7)

9 (5-15)

16 (6-30)^a

IL-6 (pg/g of protein)

AKI-INF

2 (1-5)

62 (5-104)

70 (33-130)^a

155 (67-383)^a

AKI-PERIT

3 (1-8)

118 (28-327)

246 (70-1,161)^a

284 (68-3,981)^a

NONAKI-INF

2 (2-5)

6 (5-10)

32 (27-51)^a

61 (18-84)^a

NONAKI-PERIT

3 (1-4)

12 (6-29)

19 (5-221)

33 (7-1,186)^a

NOx (μmol/g of protein)

AKI-INF

0.8 (0.6-1)

0.7 (0.6-0.7)

0.9 (0.7-1.4)

1.3 (0.9-1.5)

AKI-PERIT

0.8 (0.6-1.1)

1.6 (1.2-3)^ad

1.6 (1.3-3.5)^a

1.1 (1-2.1)

NONAKI-INF

0.9 (0.6-1.1)

0.5 (0.4-0.8)

0.7 (0.5-1)

0.8 (0.7-1.4)

NONAKI-PERIT

0.8 (0.7-0.9)

1.2 (1-1.5)

1.3 (0.8-1.7)

1.5 (1.3-1.7)^a

TBARS (pg/g of protein)

AKI-INF

14 (11-15)

26 (14-41)

31 (24-36)^a

36 (27-61)^a

AKI-PERIT

21 (18-25)^d

68 (49-93)^ad

90 (58-129)^ad

75 (55-132)^a

NONAKI-INF

14 (13-14)

22 (19-23)

32 (22-39)^a

30 (27-40)^a

NONAKI-PERIT

18 (16-21)

35 (32-48)

77 (44-91)^a

62 (39-106)^a