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Table 2 Characteristics of animals with and without S-AKI

From: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

 

Baseline

12 hours

18 hours

22 hours

Mean arterial pressure (mm Hg)

AKI

106 (97-115)

82 (72-99)a

82 (70-96)a

76 (62-88)a

Non-AKI

104 (90-114)

92 (80-100)

82 (76-91)a

78 (73-87)a

Control

95 (87-109)

87 (83-94)

80 (73-90)

84 (68-87)

Cardiac output (ml/kg)

AKI

93 (68-103)

103 (94-139)

125 (97-157)b

107 (93-153)

Non-AKI

85 (79-97)

106 (76-137)

109 (82-129)a

145 (98-168)ab

Control

98 (90-105)

97 (85-100)

80 (76-87)

85 (77-98)

Systemic vascular resistance (dyne.s.cm -5 )

AKI

2,693 (1,912-2,826)

1,437 (846-1,840)ab

1,097 (722-1,333)ab

1,121 (809-1,663)ab

Non-AKI

2,477 (2,355-2,712)

1,676 (1,539-1,973)a

1,489 (1,282-1,699)ab

1,113 (819-1,668)ab

Control

2,453 (1,838-2,700)

2,075 (1,935-2,299)

1,961 (1,872-2,169)

1,912 (1,648-2,262)

ITBVI (ml/kg)

AKI

23 (21-29)

25 (19-30)

27 (22-31)

21 (18-24)

Non-AKI

26 (23-29)

26 (23-30)

24 (21-26)

24 (22-29)

Control

31 (28-33)

24 (21-34)

23 (21-30)

26 (23-28)

Fluid intake (ml/kg/h)

AKI

12 (9-14)

16 (15-17)a

18 (14-18)a

13 (9-16)

Non-AKI

13 (12-15)

18 (17-22)a

18 (17-22)

17 (13-22)

Control

13 (11-17)

16 (13-21)

13 (13-18)

13 (10-15)

VO 2 systemic (ml/min/kg)

AKI

4.8 (4.6-5.2)

6.0 (5.0-7.4)

5.6 (4.8-7.0)

5.8 (4.2-8.6)

Non-AKI

4.4 (4.1-5.1)

5.4 (4.9-6.2)

5.3 (4.6-6.1)

4.2 (3.5-7.3)

Control

5.6 (4.6-5.9)

5.5 (5.2-5.7)

4.8 (4.7-5.8)

3.3 (2.7-4.3)a

Arterial base excess (mmol/L)

AKI

6 (5-8.5)

4 (-0.6-7.5)

2.7 (-8.6-6.5)

1.4 (-8.7-3.8)ab

Non-AKI

6.6 (4.7-11.8)

5.6 (4.7-8.5)

4.1 (2.7-6.7)

2.2 (1.1-7.7)a

Control

8.5 (6.9-12.6)

7.7 (6.7-8.3)

7.6 (5.1-11.2)

6.1 (5.1-7.3)

Arterial lactate-to-pyruvate ratio

AKI

10 (5-18)

15 (10-23)

36 (19-72)a

38 (21-60)a

Non-AKI

10 (8-22)

12 (10-15)

22 (10-39)

20 (10-85)

Control

9 (8-26)

17 (12-29)

17 (11-75)

15 (10-37)

NOx (μmol/g of protein)

AKI

0.8 (0.6-1)

1 (0.7-1.7)

1.4 (1-2)

1.3 (1-1.7)a

Non-AKI

0.8 (0.7-1)

0.8 (0.5-1.2)

0.9 (0.7-1.3)

1 (0.8-1.7)a

Control

1.1 (0.8-1.4)

0.6 (0.5-0.7)a

0.7 (0.6-0.9)

0.8 (0.6-1)

  1. Control, sham-operated group; IL-6, interleukin 6; Infusion, sepsis induced by bacterial infusion; ITBV, intrathoracic blood volume; NOx, nitrite/nitrate concentration; PaO2/FiO2, ratio between arterial oxygen tension and the inspired fraction; Peritonitis, peritonitis-induced group, TBARS, thiobarbituric acid-reactive species; VO2 systemic, systemic oxygen uptake; asignificant difference within each group versus baseline (P < 0.05); bsignificant difference between the Control group and any of the septic groups (P < 0.05).