From: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study
Baseline | 12 hours | 18 hours | 22 hours | |
---|---|---|---|---|
Mean arterial pressure (mm Hg) | ||||
AKI | 106 (97-115) | 82 (72-99)a | 82 (70-96)a | 76 (62-88)a |
Non-AKI | 104 (90-114) | 92 (80-100) | 82 (76-91)a | 78 (73-87)a |
Control | 95 (87-109) | 87 (83-94) | 80 (73-90) | 84 (68-87) |
Cardiac output (ml/kg) | ||||
AKI | 93 (68-103) | 103 (94-139) | 125 (97-157)b | 107 (93-153) |
Non-AKI | 85 (79-97) | 106 (76-137) | 109 (82-129)a | 145 (98-168)ab |
Control | 98 (90-105) | 97 (85-100) | 80 (76-87) | 85 (77-98) |
Systemic vascular resistance (dyne.s.cm -5 ) | ||||
AKI | 2,693 (1,912-2,826) | 1,437 (846-1,840)ab | 1,097 (722-1,333)ab | 1,121 (809-1,663)ab |
Non-AKI | 2,477 (2,355-2,712) | 1,676 (1,539-1,973)a | 1,489 (1,282-1,699)ab | 1,113 (819-1,668)ab |
Control | 2,453 (1,838-2,700) | 2,075 (1,935-2,299) | 1,961 (1,872-2,169) | 1,912 (1,648-2,262) |
ITBVI (ml/kg) | ||||
AKI | 23 (21-29) | 25 (19-30) | 27 (22-31) | 21 (18-24) |
Non-AKI | 26 (23-29) | 26 (23-30) | 24 (21-26) | 24 (22-29) |
Control | 31 (28-33) | 24 (21-34) | 23 (21-30) | 26 (23-28) |
Fluid intake (ml/kg/h) | ||||
AKI | 12 (9-14) | 16 (15-17)a | 18 (14-18)a | 13 (9-16) |
Non-AKI | 13 (12-15) | 18 (17-22)a | 18 (17-22) | 17 (13-22) |
Control | 13 (11-17) | 16 (13-21) | 13 (13-18) | 13 (10-15) |
VO 2 systemic (ml/min/kg) | ||||
AKI | 4.8 (4.6-5.2) | 6.0 (5.0-7.4) | 5.6 (4.8-7.0) | 5.8 (4.2-8.6) |
Non-AKI | 4.4 (4.1-5.1) | 5.4 (4.9-6.2) | 5.3 (4.6-6.1) | 4.2 (3.5-7.3) |
Control | 5.6 (4.6-5.9) | 5.5 (5.2-5.7) | 4.8 (4.7-5.8) | 3.3 (2.7-4.3)a |
Arterial base excess (mmol/L) | ||||
AKI | 6 (5-8.5) | 4 (-0.6-7.5) | 2.7 (-8.6-6.5) | 1.4 (-8.7-3.8)ab |
Non-AKI | 6.6 (4.7-11.8) | 5.6 (4.7-8.5) | 4.1 (2.7-6.7) | 2.2 (1.1-7.7)a |
Control | 8.5 (6.9-12.6) | 7.7 (6.7-8.3) | 7.6 (5.1-11.2) | 6.1 (5.1-7.3) |
Arterial lactate-to-pyruvate ratio | ||||
AKI | 10 (5-18) | 15 (10-23) | 36 (19-72)a | 38 (21-60)a |
Non-AKI | 10 (8-22) | 12 (10-15) | 22 (10-39) | 20 (10-85) |
Control | 9 (8-26) | 17 (12-29) | 17 (11-75) | 15 (10-37) |
NOx (μmol/g of protein) | ||||
AKI | 0.8 (0.6-1) | 1 (0.7-1.7) | 1.4 (1-2) | 1.3 (1-1.7)a |
Non-AKI | 0.8 (0.7-1) | 0.8 (0.5-1.2) | 0.9 (0.7-1.3) | 1 (0.8-1.7)a |
Control | 1.1 (0.8-1.4) | 0.6 (0.5-0.7)a | 0.7 (0.6-0.9) | 0.8 (0.6-1) |