| SPH (n= 679) |  |  |  | VASST (n= 517) |  |  |  |
---|---|---|---|---|---|---|---|---|
IL17A rs1974226 G/A | AA | AG | GG | Â | AA | AG | GG | Â |
 | (n = 39) | (n = 174) | (n = 466) | P | (n = 19) | (n = 162) | (n = 336) | P |
Age-years | 60(47-73) | 60(47-71) | 59(46-72) | 0.96 | 60(47-71) | 66(51-74) | 63(51-72) | 0.57 |
Gender -% male | 76.9 | 60.3 | 67.2 | 0.089 | 57.9 | 55.6 | 63.7 | 0.21 |
APACHE II | 21(17-28) | 23(17-29) | 23(18-29) | 0.74 | 25(19-35) | 26(21-32) | 27(22-31) | 0.63 |
Surgical -% | 30.8 | 32.2 | 27.3 | 0.45 | 21.1 | 22.8 | 20.5 | 0.84 |
Septic shock-n(%) | 26 (5.7) | 125 (27.6) | 302 (66.7) | 0.24 | 19 (3.7) | 162 (31.3) | 336 (65.0) | NA |
Preexisting disease-n(%) | Â | Â | Â | Â | Â | Â | Â | Â |
   Chronic heart failure | 2(5.1) | 13(7.5) | 25(5.4) | 0.59 | 1(5.3) | 13(8.0) | 27(8.0) | 0.91 |
   Chronic lung disease | 5(12.8) | 41(23.6) | 79(17.0) | 0.10 | 1(5.3) | 39(24.1) | 55(16.4) | 0.037 |
   Chronic liver disease | 4(10.3) | 16(9.2) | 49(10.5) | 0.89 | 1(5.3) | 15(9.3) | 36(10.7) | 0.69 |
   Chronic renal failure | 1(2.6) | 9(5.2) | 15(3.2) | 0.47 | 2(10.5) | 16(9.9) | 36(10.7) | 0.96 |
Vasopressin-n(%) | 3(7.7) | 27(15.5) | 63(13.5) | 0.43 | 9(47.4) | 86(53.1) | 168(50.0) | 0.77 |
Corticosteroidsa -n(%) | 9(23.1) | 68(39.1) | 156(33.5) | 0.13 | 11(57.9) | 85(52.5) | 184(54.8) | 0.84 |
Corticosteroids-day | 4(1-20) | 6(2-16) | 4(2-12) | 0.61 | 10(6-21) | 8(5-16) | 8(4-14) | 0.64 |
Activated protein C-n(%) | 1(2.6) | 4(2.3) | 22(4.7) | 0.34 | 0(0) | 27(16.7) | 43(12.8) | 0.11 |
Variables-Day1 | Â | Â | Â | Â | Â | Â | Â | Â |
Body temperature-C° | 37.8(37.1-38.5) | 37.9(37.0-38.6) | 37.9(36.6-38.6) | 0.73 | 38.8(37.6-39.3) | 38.5(37.5-39.1) | 38.5(37.6-39.3) | 0.85 |
Heart rate -/min | 115(105-120) | 106(95-126) | 112(95-130) | 0.67 | 126(107-140) | 128(115-140) | 125(106-137) | 0.12 |
MAP-mmHg | 59(52-71) | 57(51-65) | 58(52-68) | 0.34 | 58(51-63) | 56(50-61) | 55(50-61) | 0.60 |
WBC-103/mm3 | 12.9(9.0-17.1) | 15.0(9.3-21.7) | 13.5(9.3-18.9) | 0.075 | 14.3(4.6-19.6) | 13.4(8.3-19.9) | 13.9(7.7-21.3) | 0.69 |
Platelet-103/mm3 | 149(97-183) | 191(113-261) | 171(95-259) | 0.091 | 150(123-224) | 145(74-246) | 165(86-263) | 0.44 |
PaO2/FIO2 ratio-mmHg | 162(106-234) | 154(106-224) | 158(98-229) | 0.84 | 233(182-317) | 198(153-263) | 190(131-251) | 0.040 |
Creatinine -μmol/L | 165(73-295) | 112(73-240) | 126(80-231) | 0.50 | 190(96-297) | 149(90-228) | 154(90-270) | 0.38 |