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Table 3 Baseline characteristics in two cohorts of severe sepsis patients by the genotype of IL17A rs1974226 polymorphism.

From: IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis

 

SPH (n= 679)

   

VASST (n= 517)

   

IL17A rs1974226 G/A

AA

AG

GG

 

AA

AG

GG

 
 

(n = 39)

(n = 174)

(n = 466)

P

(n = 19)

(n = 162)

(n = 336)

P

Age-years

60(47-73)

60(47-71)

59(46-72)

0.96

60(47-71)

66(51-74)

63(51-72)

0.57

Gender -% male

76.9

60.3

67.2

0.089

57.9

55.6

63.7

0.21

APACHE II

21(17-28)

23(17-29)

23(18-29)

0.74

25(19-35)

26(21-32)

27(22-31)

0.63

Surgical -%

30.8

32.2

27.3

0.45

21.1

22.8

20.5

0.84

Septic shock-n(%)

26 (5.7)

125 (27.6)

302 (66.7)

0.24

19 (3.7)

162 (31.3)

336 (65.0)

NA

Preexisting disease-n(%)

        

   Chronic heart failure

2(5.1)

13(7.5)

25(5.4)

0.59

1(5.3)

13(8.0)

27(8.0)

0.91

   Chronic lung disease

5(12.8)

41(23.6)

79(17.0)

0.10

1(5.3)

39(24.1)

55(16.4)

0.037

   Chronic liver disease

4(10.3)

16(9.2)

49(10.5)

0.89

1(5.3)

15(9.3)

36(10.7)

0.69

   Chronic renal failure

1(2.6)

9(5.2)

15(3.2)

0.47

2(10.5)

16(9.9)

36(10.7)

0.96

Vasopressin-n(%)

3(7.7)

27(15.5)

63(13.5)

0.43

9(47.4)

86(53.1)

168(50.0)

0.77

Corticosteroidsa -n(%)

9(23.1)

68(39.1)

156(33.5)

0.13

11(57.9)

85(52.5)

184(54.8)

0.84

Corticosteroids-day

4(1-20)

6(2-16)

4(2-12)

0.61

10(6-21)

8(5-16)

8(4-14)

0.64

Activated protein C-n(%)

1(2.6)

4(2.3)

22(4.7)

0.34

0(0)

27(16.7)

43(12.8)

0.11

Variables-Day1

        

Body temperature-C°

37.8(37.1-38.5)

37.9(37.0-38.6)

37.9(36.6-38.6)

0.73

38.8(37.6-39.3)

38.5(37.5-39.1)

38.5(37.6-39.3)

0.85

Heart rate -/min

115(105-120)

106(95-126)

112(95-130)

0.67

126(107-140)

128(115-140)

125(106-137)

0.12

MAP-mmHg

59(52-71)

57(51-65)

58(52-68)

0.34

58(51-63)

56(50-61)

55(50-61)

0.60

WBC-103/mm3

12.9(9.0-17.1)

15.0(9.3-21.7)

13.5(9.3-18.9)

0.075

14.3(4.6-19.6)

13.4(8.3-19.9)

13.9(7.7-21.3)

0.69

Platelet-103/mm3

149(97-183)

191(113-261)

171(95-259)

0.091

150(123-224)

145(74-246)

165(86-263)

0.44

PaO2/FIO2 ratio-mmHg

162(106-234)

154(106-224)

158(98-229)

0.84

233(182-317)

198(153-263)

190(131-251)

0.040

Creatinine -μmol/L

165(73-295)

112(73-240)

126(80-231)

0.50

190(96-297)

149(90-228)

154(90-270)

0.38

  1. APACHE, Acute Physiology and Chronic Health Evaluation; MAP, mean arterial pressure; n, number; NA, not applicable; SPH, St Paul's Hospital; VASST, Vasopressin and Septic Shock Trial; WBC, white blood cell count.
  2. aCorticosteroids, low dose corticosteroid.
  3. Data are median (interquartile range) for continuous variables. P values were calculated with the use of chi-square test and Kruskal Wallis test.