IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis

Table 2 Allele frequency and association of interleukin17A polymorphisms with Gram-positive bacterial infection in the derivation cohort of severe sepsis.

	Location^a base pair	Major/minor allele	MAF (HapMap^b)	HWE P value^c	Odds Ratio (95% CI)	P value^d (Corrected P value^e)
rs4711998	-832	G/A	0.326 (0.217)	0.025	1.13 (0.80-1.60)	0.48
rs8193036	-692	T/C	0.287 (0.241)	0.53	1.41 (0.97-2.05)	0.073
rs2275913	-399	G/A	0.331 (0.383)	0.79	1.45 (1.01-2.10)	0.045 (0.18)
rs1974226	+4150 (3' UTR)	G/A	0.182 (0.179)	0.10	1.89 (1.22-2.92)	0.0037 (0.015)

HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; UTR, untranslated region.
^aRelative distance to transcription start site; ^bMinor allele frequency of HapMap Utah residents with Northern and Western European ancestry from the Centre d'Etude du Polymorphisme Humain collection (CEU) data; ^cHardy-Weinberg equilibrium P values for culture positive patients were calculated using the chi-square test; ^dP values were calculated using Armitage's test and corrected for multiple comparison by a Bonferroni test^e.

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