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Table 1 Characteristics of culture-positive patients in two cohorts of severe sepsis

From: IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis

 

SPH

 

VASST

 
 

Culture Positive

All

Culture Positive

All

 

( n = 301)

(n = 679)

(n = 282)

(n = 517)

Age-years

58 (45-71)

59 (46-72)

63 (50-73)

63 (51-73)

Gender -% male

65.4

66.0

60.3

60.9

APACHE II

24 (18-30)

23 (18-29)

26 (21-31)

26 (21-32)

Surgical -%

26.6

28.7

19.1

21.3

Septic shock-number (%)

208 (69.1)

453 (66.7)

282 (100)

517 (100)

Pathogens-number (%)

    

   Gram-positive bacteria alone

152 (50.5)

 

115 (40.8)

 

   Gram-negative bacteria alone

100 (33.2)

 

82 (29.1)

 

   Fungus alone

9 (3.0)

 

37 (13.1)

 

   Mixed

40 (13.3)

 

48 (17.0)

 

Source of a positive culture-number (%)

    

   Lung

126 (41.9)

 

140 (49.6)

 

   Blood

115 (38.2)

 

131 (46.5)

 

   Abdomen

20 (6.6)

 

53 (18.8)

 

   Skin and soft tissue

21 (7.0)

 

36 (12.8)

 

   Genitourinary system

16 (5.3)

 

17 (6.0)

 

   Other

3 (1.0)

 

29 (10.3)

 
  1. APACHE, Acute Physiology and Chronic Health Evaluation; SPH, St. Paul's Hospital; VASST, Vasopressin and Septic Shock Trial
  2. Data are median (interquartile range) for continuous variables.