M1 and M2 macrophage markers in adipose tissue from healthy controls and critically ill, non-surviving patients. Adipose tissue (A.T.) mRNA levels of (A) TNF-α, (B) Arginase-1, (C) CD163, (D) and IL-10 (D). (E) Adipose tissue biopsy staining for CD163 from one representative patient, and (F) serum IL-10 levels on the day of sampling. Databoxes present median and interquartile range; whiskers represent the 10th and the 90th percentiles. Grey boxes represent healthy controls undergoing elective surgery (healthy, n = 20); white boxes are critically ill patients (crit. Ill, n = 61). Different from healthy controls with *P ≤ 0.05, ** P ≤ 0.01. AU, arbitrary units.