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Table 2 Comparison of immunological parameters based upon ICU mortality

From: Early natural killer cell counts in blood predict mortality in severe sepsis

  ICU mortality from day 1
(N= 50)
  ICU mortality from day 3
(N= 40)
  ICU mortality from day 10
(N= 37)
 
Immunological parameters Survivors
( n = 29)
Nonsurvivors
( n = 21)
P value Survivors
( n = 29)
Nonsurvivors
( n = 11)
P value Survivors
( n = 28)
Nonsurvivors
( n = 9)
P
value
IgG (mg/dl) 844.0 (447.5) 616.0 (442.5) 0.035 932.0 (371.0) 685.0 (538.0) 0.007 1,080.0 (602.2) 764.0 (1068.0) n.s.
IgA (mg/dl) 240.0 (128.0) 184.0 (167.0) n.s. 280.0 (144.0) 240.0 (209.0) n.s. 334.0 (164.0) 257.0 (580.8) n.s.
IgM (mg/dl) 53.0 (47.0) 60.0 (53.0) n.s. 70.0 (85.0) 67.0 (61.0) n.s. 79.5 (66.5) 42.0 (86.0) n.s.
C3 (mg/dl) 101.5 (52.3) 79.0 (60.5) n.s. 108.0 (55.0) 110.0 (89.0) n.s. 135.0 (49.0) 106.0 (81.0) n.s.
C4 (mg/dl) 24.0 (19.0) 17.0 (16.0) 0.029 24.0 (16.5) 28.0 (22.0) n.s. 32.0 (18.0) 20.0 (10.0) n.s.
CD3+ T (cells/mm3) 417.0 (706.5) 419.0 (585.0) n.s. 639.5 (636.3) 472.0 (415.0) n.s. 774.0 (463.5) 561.0 (552.0) n.s.
CD4+ T (cells/mm3) 288.0 (474.5) 198.0 (400.0) n.s. 372.5 (525.8) 366.0 (423.0) n.s. 519.0 (339.0) 347.0 (355.0) n.s.
CD8+ T (cells/mm3) 114.0 (258.0) 156.0 (231.0) n.s. 249.5 (199.0) 120.0 (145.0) n.s. 287.0 (296.0) 204.0 (314.0) n.s.
CD4+ CD8+ T (cells/mm3) 5.0 (12.0) 6.0 (13.5) n.s. 5.0 (9.0) 6.5 (24.0) n.s. 12.0 (18.3) 6.0 (54.0) n.s.
LB (cells/mm3) 103.0 (165.5) 184.0 (281.0) n.s. 163.0 (125.0) 127.0 (168.0) n.s. 118.0 (151.0) 92.0 (131.0) n.s.
NK (cells/mm3) 56.8 (59.5) 98.0 (392.0) 0.050 59.5 (72.5) 42.0 (73.0) n.s. 86.0 (78.0) 92.0 (38.0) n.s.
  1. Data are expressed as medians (IQR). n.s. = not significant. Normal values in adult healthy individuals are as follows: immunoglobulin G (IgG) = 870 to 2,180 mg/dl, IgA = 117 to 420 mg/dl; IgM = 60 to 220 mg/dl; CD3+ T cells = 690 to 2,540 cells/mm3; CD4+ T cells = 410 to 1,590 cells/mm3; CD8+ T cells = 190 to 1,140 cells/mm3; CD4+ CD8+ T cells = not available; B lymphocytes (LB) = 90 to 660 cells/mm3; natural killer (NK) cells = 90 to 590 cells/mm3; complement factor 3 (C3) = 50 to 120 mg/dl; complement factor 4 (C4) = 14 to 70 mg/dl.