Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction

Table 2 Hemodynamic data

Clinical parameters	HR (beats/minute)	MAP (mmHg)	CVP (mmHg)	CI (L/minute/m²)
Baseline
CONTROL	57 ± 21	88 ± 33	5 ± 2	3.8 ± 0.5
SEVO	65 ± 11	71 ± 14	4 ± 2	3.8 ± 0.7
1-hour ROSC
CONTROL	116 ± 26	82 ± 8	8 ± 3	4.4 ± 1.3
SEVO	108 ± 11	74 ± 19	7 ± 2	5.1 ± 0.9
2-hour ROSC
CONTROL	95 ± 19	76 ± 17	6 ± 1	4.4 ± 1.0
SEVO	109 ± 12	81 ± 13	6 ± 1	5.7 ± 1.7
4-hour ROSC
CONTROL	97 ± 21	76 ± 16	8 ± 2	5.0 ± 1.7
SEVO	101 ± 19	74 ± 13	7 ± 2	5.5 ± 1.6
24-hour ROSC
CONTROL	75 ± 15	65 ± 9	8 ± 3	4.0 ± 0.8
SEVO	69 ± 15	69 ± 15	7 ± 2	3.4 ± 0.6

Hemodynamic data were determined at baseline and 1, 2, 4 and 24 hours after return of spontaneous circulation (ROSC) in the propofol (CONTROL) and sevoflurane (SEVO) groups. Data are means ± SD. Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP) and cardiac index (CI) did not differ significantly between groups after we applied the Bonferroni correction for repeated time measurements using two-way analysis of variance. Cardiac index was calculated as the ratio of cardiac output to body surface area (body surface area = 0.0734 × (body weight in kilograms)^0.656) [10].

ISSN: 1364-8535