Experimental time line. Twenty-two pigs were subjected to cardiac arrest. After 8 minutes of ventricular fibrillation (VF), pigs were resuscitated (cardiopulmonary resuscitation, CPR). Immediately after successful return of spontaneous circulation (ROSC; N = 16), the animals were randomized to either (1) total intravenous anesthesia maintained by continuous infusion of propofol (4 mg/kg/hour; CONTROL) or (2) the volatile anesthetic sevoflurane (SEVO) at 1.5 minimum alveolar concentration (3% end-tidal volume) with an initial three interrupted cycles of wash-in (6% end-tidal volume for 5 minutes) and wash-out (0.5% end-tidal volume for 5 minutes) for 4 hours. Neurological function was assessed 24 hours after ROSC by neurological deficit score (NDS) of 1 or 2. Subsequently, animals were again anesthetized using propofol to determine myocardial function by echocardiography, then the animals were killed by an overdose of anesthetic to collect myocardial and cerebral tissue samples. cTnT = cardiac troponin T; TEE = transesophageal echocardiography.