Table 2 Comparison of clinical characteristics at Day-1 and outcome between patients with tobramycin leakage and without
Without tobramycin leakage n= 17 | With tobramycin leakage n= 83 | P-value | |
|---|---|---|---|
Baseline | |||
Age (years) | 62 (49.5 to 69.5) | 68 (59.0 to 76.0) | 0.06 |
BMI | 25.2 (22.7 to 27.7) | 27.2 (24.1 to 29.3) | 0.11 |
SOFA score | 10 (7 to 11) | 9 (7 to 12) | 0.60 |
APACHE II score | 25 (21 to 33) | 27 (20 to 35) | 0.61 |
APACHE II PM | 59 (40 to 83) | 61 (31 to 84) | 0.78 |
SAPS II score | 58 (46 to 66) | 59 (44 to 73) | 0.81 |
SAPS II PM | 64 (37 to 78) | 65 ((33 to 87) | 0.79 |
APACHE III score | 101 (70 to 124) | 97 (73 to 132) | 0.96 |
APACHE IV PM | 61 (25 to 82) | 56 (25 to 90) | 0.87 |
Sepsis | 5 (29.4) | 27 (32.5) | 1.00 |
CRP (mg/L) | 3 (2 to 94) | 37 (4 to 169) | 0.06 |
Lowest MAP (mmHg) | 78 (65 to 99) | 79 (61 to 94) | 0.90 |
Dopamine dose (μg/kg/minute) | 3.3 (2.2 to 5.9) | 6.7 (2.8 to 17.2) | 0.02 |
Noradrenalin dose (μg/kg/minute) | 0.00 (0.00 to 0.00) | 0.00 (0.00 to 0.05) | 0.09 |
Fluid balance (ml) | 3,450 (548 to 4,646) | 3,074 (1,323 to 4,528) | 0.99 |
Lowest PO2 mmHg | 75 (61.0 to 83.5) | 70 (60.8 to 82.0) | 0.53 |
PF ratio (mmHg/fraction) | 206 (125 to 276) | 206 (156 to 300) | 0.72 |
Lowest pH | 7.21 (7.08 to 7.27) | 7.21 (7.09 to 7.29) | 0.68 |
Creatinine before hospital admission (μmol/L) | 83 (64.0 to 101.5) | 77 (56.0 to 96.5) | 0.43 |
Creatinine admission (μmol/L) | 98 (75 to 129) | 99 (69 to 144) | 0.92 |
Creatinine d2 (μmol/L) | 87 (59 to 101) | 95 (70 to 144) | 0.24 |
Urinary output (ml) | 3,645 (1,893 to 4,608) | 2,150 (1,092 to 3,585) | 0.05 |
Urinary output (ml/kg/h) | 1.8 (1.07 to 2.85) | 1.0 (0.55 to 1.88) | 0.04 |
RIFLE 1,2,3 c | |||
0 | 13 (77) | 45 (56) | 0.40 |
1 | 2 (12) | 11 (14) | |
2 | 1 (6) | 14 (17) | |
3 | 1 (6) | 11 (14) | |
Bilirubin (μmol/L) | 6 (4 to 13) | 9 (6 to 17) | 0.07 |
Hemoglobin (mmol/L) | 7.5 (5.5 to 8.8) | 6.8 (5.9 to 8.2) | 0.34 |
Platelets (giga) | 214 (165 to 276) | 200 (148 to 300) | 0.75 |
Gastric retention (ml/day) | 450 (215.0 to 777.0) | 250 (112.5 to 660.0) | 0.18 |
Outcome | |||
CVVH during ICU admission | 3 (18%) | 22 (27%) | 0.55 |
Duration mechanical ventilation (h) | 42 (32 to 76) | 62 (25 to 114) | 0.72 |
LOS ICU (days) | 2.2 (1.8 to 4.0) | 3.4 (2.0 to 6.2) | 0.29 |
Creatinine hospital discharge (μmol/L) | 99 (59 to 129) | 82 (58 to 147) | 0.69 |
Creatinine hospital discharge/ creatinine pre-admission | 1.13 (1.02 to 1.32) | 1.16 (1.00 to 1.54) | 0.81 |
Mortality hospital n (%) | 6 (35) | 25 (30) | 0.46 |