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Table 9 Evidence for the effect of each intervention on plasma fibrinogen levels

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

  FFP outcomes: plasma fibrinogen levels Fibrinogen concentrate outcomes: plasma fibrinogen levels
Type of study Increased/higher No difference Decreased/lower Increased/higher No difference Decreased/lower
RCT 2 (vs preadministration) [38, 43]
1 (vs comparator) [41]
3 (vs preadministration/comparator) [22, 49, 64] 1 (vs preadministration) [108] 2 (vs comparator) [54, 71] - -
Non RCT or prospective comparator 1 (vs comparator) [23] 1 (vs preadministration/comparator) [109] 1 (vs comparator) [44] 1 (vs comparator) [55] - -
Retrospective comparator 1 (vs comparator) [30] - - 1 (vs comparator) [26] - -
Controlled and/or comparator study outcomes, n (percentage of outcomes within intervention group) 5 (46%) 4 (36%) 2 (18%) 4 (100%) 0 0
Prospective noncomparator 1 (vs preadministration) [53] - - - - -
Retrospective noncomparator 1 (vs preadministration) [70] - 1 (vs preadministration) [110] 6 (vs preadministration) [59, 7274, 104, 115] - -
Case report - - 2 (vs preadministration) [51, 111] 7 (vs preadministration) [6062, 112114, 116] - -
Study outcomes, n (percentage of outcomes within intervention group) 7 (44%) 4 (25%) 5 (31%) 17 (100%) 0 0
  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data.