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Table 9 Evidence for the effect of each intervention on plasma fibrinogen levels

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

 

FFP outcomes: plasma fibrinogen levels

Fibrinogen concentrate outcomes: plasma fibrinogen levels

Type of study

Increased/higher

No difference

Decreased/lower

Increased/higher

No difference

Decreased/lower

RCT

2 (vs preadministration) [38, 43]

1 (vs comparator) [41]

3 (vs preadministration/comparator) [22, 49, 64]

1 (vs preadministration) [108]

2 (vs comparator) [54, 71]

-

-

Non RCT or prospective comparator

1 (vs comparator) [23]

1 (vs preadministration/comparator) [109]

1 (vs comparator) [44]

1 (vs comparator) [55]

-

-

Retrospective comparator

1 (vs comparator) [30]

-

-

1 (vs comparator) [26]

-

-

Controlled and/or comparator study outcomes, n (percentage of outcomes within intervention group)

5 (46%)

4 (36%)

2 (18%)

4 (100%)

0

0

Prospective noncomparator

1 (vs preadministration) [53]

-

-

-

-

-

Retrospective noncomparator

1 (vs preadministration) [70]

-

1 (vs preadministration) [110]

6 (vs preadministration) [59, 72–74, 104, 115]

-

-

Case report

-

-

2 (vs preadministration) [51, 111]

7 (vs preadministration) [60–62, 112–114, 116]

-

-

Study outcomes, n (percentage of outcomes within intervention group)

7 (44%)

4 (25%)

5 (31%)

17 (100%)

0

0

  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data.