Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

Table 8 Evidence for the effect of each intervention on ICU and/or hospital length of stay

	FFP outcomes: ICU and/or hospital length of stay			Fibrinogen concentrate outcomes: ICU and/or hospital length of stay
Type of study	Reduced	No difference	Increased	Reduced	No difference	Increased
RCT	-	1 (ICU) [50]	-	1 (ICU) [56] 1 (hospital) [56]	-	-
Non RCT or prospective comparator	1 (hospital) [24]	2 (ICU) [24, 87] 1 (hospital) [87]	1 (ICU) [77] 1 (hospital) [77]	1 (ICU) [55]	1 (hospital) [55]	-
Retrospective comparator	1 (ICU) [32, 33]	2 (ICU) [3, 79] 5 (hospital) [3, 39, 40, 66, 79]	7 (ICU) [39, 66, 67, 69, 81, 83, 105]* 3 (hospital) [67, 69, 81]	1 (ICU) [26]	1 (hospital) [26]	-
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group)	2 (8%)	11 (44%)	12 (48%)	4 (67%)	2 (33%)	0
Prospective noncomparator	-	-	-	-	-	-
Retrospective noncomparator	-	1 (ICU) [107] 1 (hospital) [107]	2 (ICU) [98, 106]	-	-	-
Case report	-	-	-	-	-	-
Study outcomes, n (percentage of outcomes within intervention group)	2 (7%)	13 (45%)	14 (48%)	4 (67%)	2 (33%)	0

FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. *For Oberkofler 2010 [83], this represented an increased risk of ICU stay > 10 days.