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Table 8 Evidence for the effect of each intervention on ICU and/or hospital length of stay

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

  FFP outcomes: ICU and/or hospital length of stay Fibrinogen concentrate outcomes:
ICU and/or hospital length of stay
Type of study Reduced No difference Increased Reduced No difference Increased
RCT - 1 (ICU) [50] - 1 (ICU) [56]
1 (hospital) [56]
- -
Non RCT or prospective comparator 1 (hospital) [24] 2 (ICU) [24, 87]
1 (hospital) [87]
1 (ICU) [77]
1 (hospital) [77]
1 (ICU) [55] 1 (hospital) [55] -
Retrospective comparator 1 (ICU) [32, 33] 2 (ICU) [3, 79]
5 (hospital)
[3, 39, 40, 66, 79]
7 (ICU) [39, 66, 67, 69, 81, 83, 105]*
3 (hospital) [67, 69, 81]
1 (ICU) [26] 1 (hospital) [26] -
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) 2 (8%) 11 (44%) 12 (48%) 4 (67%) 2 (33%) 0
Prospective noncomparator - - - - - -
Retrospective noncomparator - 1 (ICU) [107]
1 (hospital) [107]
2 (ICU) [98, 106] - - -
Case report - - - - - -
Study outcomes, n (percentage of outcomes within intervention group) 2 (7%) 13 (45%) 14 (48%) 4 (67%) 2 (33%) 0
  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. *For Oberkofler 2010 [83], this represented an increased risk of ICU stay > 10 days.