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Table 6 Evidence for the effect of each intervention on allogeneic transfusions

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

  FFP outcomes: allogeneic transfusions Fibrinogen concentrate outcomes: allogeneic transfusions
Type of study Reduction No difference Increase Reduction No difference Increase
RCT - 3 (postoperative) [3537]
6 (perioperative) [22, 41, 43, 49, 64, 65]
1 (intraoperative) [50]; 1 (postoperative) [50] 2 (postoperative) [56, 71] 2 (intraoperative) [56, 71]
1 (postoperative) [54]
-
Non RCT or prospective comparator - 1 (intraoperative) [23]
1 (postoperative) [23]
1 (postoperative) [44] 1 (postoperative) [55] - -
Retrospective comparator 1 (postoperative) [39]
1 > 24 hours postoperative) [30]
3 (total) [6668]
1 (postoperative) [47]
2 ≤ 24 hours postoperative) [30, 69]
- 1 (intraoperative) [26]
1 (postoperative) [26]
- -
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) 5 (23%) 14 (63%) 3 (14%) 5 (63%) 3 (37%) 0
Prospective noncomparator - 1 (postoperative) [53] - - - -
Retrospective noncomparator 1 (postoperative) [70] - - 2 (intraoperative) [72, 73]
3 (postoperative) [59, 72, 74]
1 (perioperative) [73]
- -
Case report - - - 5 (perioperative) [57, 58, 6062] - -
Study outcomes (percentage of outcomes, n (within intervention group) 6 (25%) 15 (63%) 3 (12%) 16 (84%) 3 (16%) 0
  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. Allogeneic products are defined as any combination of packed red blood cells, FFP, platelets and/or cryoprecipitate.