Skip to main content

Table 6 Evidence for the effect of each intervention on allogeneic transfusions

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

 

FFP outcomes: allogeneic transfusions

Fibrinogen concentrate outcomes: allogeneic transfusions

Type of study

Reduction

No difference

Increase

Reduction

No difference

Increase

RCT

-

3 (postoperative) [3537]

6 (perioperative) [22, 41, 43, 49, 64, 65]

1 (intraoperative) [50]; 1 (postoperative) [50]

2 (postoperative) [56, 71]

2 (intraoperative) [56, 71]

1 (postoperative) [54]

-

Non RCT or prospective comparator

-

1 (intraoperative) [23]

1 (postoperative) [23]

1 (postoperative) [44]

1 (postoperative) [55]

-

-

Retrospective comparator

1 (postoperative) [39]

1 > 24 hours postoperative) [30]

3 (total) [6668]

1 (postoperative) [47]

2 ≤ 24 hours postoperative) [30, 69]

-

1 (intraoperative) [26]

1 (postoperative) [26]

-

-

Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group)

5 (23%)

14 (63%)

3 (14%)

5 (63%)

3 (37%)

0

Prospective noncomparator

-

1 (postoperative) [53]

-

-

-

-

Retrospective noncomparator

1 (postoperative) [70]

-

-

2 (intraoperative) [72, 73]

3 (postoperative) [59, 72, 74]

1 (perioperative) [73]

-

-

Case report

-

-

-

5 (perioperative) [57, 58, 6062]

-

-

Study outcomes (percentage of outcomes, n (within intervention group)

6 (25%)

15 (63%)

3 (12%)

16 (84%)

3 (16%)

0

  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. Allogeneic products are defined as any combination of packed red blood cells, FFP, platelets and/or cryoprecipitate.