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Table 5 Evidence for the effect of each intervention on blood loss

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

 

FFP outcomes: blood loss

Fibrinogen concentrate outcomes: blood loss

Study type

Reduction

No difference

Increase

Reduction

No difference

Increase

RCT

-

2 (intraoperative) [43, 45]

9 (postoperative) [3538, 41, 45, 4850]

-

1 (postoperative) [54]

1 (postoperative) [56]

-

Non RCT or prospective comparator

-

2 (postoperative) [23, 44]

1 (postoperative) [44]

1 (postoperative) [55]

-

-

Retrospective comparator

1 (perioperative) [34]

2 (intraoperative) [39, 40]

2 (postoperative) [46, 47]

1 (perioperative) [42]

-

1 (postoperative) [26]

-

-

Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group)

1 (5%)

18 (90%)

1 (5%)

3 (75%)

1 (25%)

0

Prospective noncomparator

-

1 (postoperative) [53]

-

-

-

-

Retrospective noncomparator

-

1 (postoperative) [52]

-

1 (perioperative) [59]

-

-

Case report

-

1 (perioperative) [51]

-

6 (perioperative) [57, 58, 6063]

-

-

Study outcomes, n (percentage of outcomes within intervention group)

1 (4%)

21 (92%)

1 (4%)

10 (91%)

1 (9%)

0

  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data.