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Table 5 Evidence for the effect of each intervention on blood loss

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

  FFP outcomes: blood loss Fibrinogen concentrate outcomes: blood loss
Study type Reduction No difference Increase Reduction No difference Increase
RCT - 2 (intraoperative) [43, 45]
9 (postoperative) [3538, 41, 45, 4850]
- 1 (postoperative) [54] 1 (postoperative) [56] -
Non RCT or prospective comparator - 2 (postoperative) [23, 44] 1 (postoperative) [44] 1 (postoperative) [55] - -
Retrospective comparator 1 (perioperative) [34] 2 (intraoperative) [39, 40]
2 (postoperative) [46, 47]
1 (perioperative) [42]
- 1 (postoperative) [26] - -
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) 1 (5%) 18 (90%) 1 (5%) 3 (75%) 1 (25%) 0
Prospective noncomparator - 1 (postoperative) [53] - - - -
Retrospective noncomparator - 1 (postoperative) [52] - 1 (perioperative) [59] - -
Case report - 1 (perioperative) [51] - 6 (perioperative) [57, 58, 6063] - -
Study outcomes, n (percentage of outcomes within intervention group) 1 (4%) 21 (92%) 1 (4%) 10 (91%) 1 (9%) 0
  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data.