Table 5 Evidence for the effect of each intervention on blood loss
| FFP outcomes: blood loss | Fibrinogen concentrate outcomes: blood loss | |||||
|---|---|---|---|---|---|---|
| Study type | Reduction | No difference | Increase | Reduction | No difference | Increase |
| RCT | - |
2 (intraoperative) [43, 45] 9 (postoperative) [35–38, 41, 45, 48–50] | - | 1 (postoperative) [54] | 1 (postoperative) [56] | - |
| Non RCT or prospective comparator | - | 2 (postoperative) [23, 44] | 1 (postoperative) [44] | 1 (postoperative) [55] | - | - |
| Retrospective comparator | 1 (perioperative) [34] |
2 (intraoperative) [39, 40] 2 (postoperative) [46, 47] 1 (perioperative) [42] | - | 1 (postoperative) [26] | - | - |
| Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) | 1 (5%) | 18 (90%) | 1 (5%) | 3 (75%) | 1 (25%) | 0 |
| Prospective noncomparator | - | 1 (postoperative) [53] | - | - | - | - |
| Retrospective noncomparator | - | 1 (postoperative) [52] | - | 1 (perioperative) [59] | - | - |
| Case report | - | 1 (perioperative) [51] | - | 6 (perioperative) [57, 58, 60–63] | - | - |
| Study outcomes, n (percentage of outcomes within intervention group) | 1 (4%) | 21 (92%) | 1 (4%) | 10 (91%) | 1 (9%) | 0 |