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Table 3 Summary details of eligible noncomparator trials

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

Study Indication Study type Patients (N) Intervention details Control group
FFP
   Aiyagari et al. (2005) [51] Trauma (gunshot injury) Case report 3 FFP 10 U, 4 U, 8 U No control group
   Dann et al. (2008) [110] Massive trauma Retrospective noncomparator 21 FFP:RBC 1:1.5 No control group
   Díaz-Gómez et al. (2010) [94] CV surgery Retrospective noncomparator 14,868 FFP No control group
   Fan et al. (2003) [95] Liver transplantation Prospective noncomparator 100 FFP No control group
   Fischer et al. (2008) [52] GI bleeding (preterms) Retrospective noncomparator 5 FFP 10 to 30 ml/kg/30 minutes No control group
   Gonzalez et al. (2007) [96] Massive trauma Retrospective noncomparator 97 FFP mean 5 U No control group
   Lei et al. (2009) [106] CV surgery Retrospective noncomparator 298 FFP mean 1,090 ml No control group
   Magner et al. (2007) [111] Liver transplantation Case report 2 SD-FFP 42 U, 16 U No control group
   Moore et al. (2008) [97] Massive trauma Prospective noncomparator 93 FFP 6.3 U No control group
Pull ter Gunne et al. (2010)
[107]
Surgery (other) Retrospective noncomparator 300 FFP mean 2.61 U No control group
   Ranucci et al. (2008) [98] CV surgery Retrospective noncomparator 4546 FFP No control group
   Schols et al. (2008) [53] Surgery (CV, abdominal or spinal bone) Prospective noncomparator 51 FFP mean 780 ml No control group
   Spinella et al. (2008) [99] Trauma Retrospective noncomparator 708 FFP mean 3 U No control group
   Stricker et al. (2010) [70] Surgery (other, paediatric) Retrospective noncomparator 159 FFP mean 20 ml/kg No control group
   Swisher et al. (1996) [100] Surgery (oesophageal resection for cancer) Retrospective noncomparator 275 FFP No control group
   Tenza et al. (2009) [101] Liver transplantation Retrospective noncomparator 74 FFP mean 15.7 U No control group
   Watson et al. (2009) [103] Trauma Retrospective noncomparator 842 FFP median 4.8 U No control group
   Wiederkehr et al. (2010) [102] Liver transplantation Retrospective noncomparator 155 FFP No control group
Fibrinogen concentrate
   Bell et al. (2010) [112] Postpartum haemorrhage Case series 6 Fibrinogen concentrate No control group
   Böhrer (1999) [57] Liver transplantation Case report 1 Fibrinogen concentrate 2 g No control group
   Brenni et al. (2010) [58] Trauma Case report 1 Fibrinogen concentrate 16 g No control group
Farriols Danés et al. (2008)
[104]
Various Retrospective noncomparator 69 Fibrinogen concentrate median 4 g No control group
Fenger-Eriksen et al. (2008)
[59]
Severe bleeding Retrospective noncomparator 43 Fibrinogen concentrate mean 2.0 g No control group
   Glover et al. (2010) [63] Postpartum haemorrhage Case report 1 Fibrinogen concentrate No control group
   Haas et al. (2008) [113] Surgery (craniofacial, paediatric) Case series 9 Fibrinogen concentrate median 76 mg/kg No control group
   Heindl et al. (2005) [116] Surgery (other) Case report 2 Fibrinogen concentrate 7 g, 8 g No control group
   Innerhofer (2006) [60] Surgery (lumbar) Case report 1 Fibrinogen concentrate 5 g No control group
   Peitsidou et al. (2008) [114] Emergency caesarean section and
Hysterectomy
Case report 1 Fibrinogen concentrate 2 g No control group
   Schöchl et al. (2010) [61] Massive trauma, then laparotomy Case report 1 Fibrinogen concentrate 13 g No control group
   Schöchl et al. (2010) [62] Trauma surgery Case report 1 Fibrinogen concentrate 12 g No control group
   Schöchl et al. (2010) [73] Trauma surgery Retrospective noncomparator 128 Fibrinogen concentrate median 7 g No control group
   Solomon et al. (2010) [72] CV surgery Retrospective noncomparator 39 Fibrinogen concentrate mean 6.5 g No control group
Thorarinsdottir et al. (2010)
[74]
Surgery (various) Retrospective noncomparator 37 Fibrinogen concentrate median 2 g No control group
   Weinkove et al. (2008) [115] Various Retrospective noncomparator 30 Fibrinogen concentrate median 4 g No control group
Other      
   Murad et al. (2010) [5] Various Meta-analysis 12,421 FFP Various
  1. CV = cardiovascular; FFP = fresh frozen plasma; GI = gastrointestinal; SD-FFP = solvent/detergent-treated fresh frozen plasma.