Table 3 Summary details of eligible noncomparator trials
Study | Indication | Study type | Patients (N) | Intervention details | Control group |
|---|---|---|---|---|---|
FFP | |||||
   Aiyagari et al. (2005) [51] | Trauma (gunshot injury) | Case report | 3 | FFP 10 U, 4 U, 8 U | No control group |
   Dann et al. (2008) [110] | Massive trauma | Retrospective noncomparator | 21 | FFP:RBC 1:1.5 | No control group |
   DÃaz-Gómez et al. (2010) [94] | CV surgery | Retrospective noncomparator | 14,868 | FFP | No control group |
   Fan et al. (2003) [95] | Liver transplantation | Prospective noncomparator | 100 | FFP | No control group |
   Fischer et al. (2008) [52] | GI bleeding (preterms) | Retrospective noncomparator | 5 | FFP 10 to 30 ml/kg/30 minutes | No control group |
   Gonzalez et al. (2007) [96] | Massive trauma | Retrospective noncomparator | 97 | FFP mean 5 U | No control group |
   Lei et al. (2009) [106] | CV surgery | Retrospective noncomparator | 298 | FFP mean 1,090 ml | No control group |
   Magner et al. (2007) [111] | Liver transplantation | Case report | 2 | SD-FFP 42 U, 16 U | No control group |
   Moore et al. (2008) [97] | Massive trauma | Prospective noncomparator | 93 | FFP 6.3 U | No control group |
Pull ter Gunne et al. (2010) [107] | Surgery (other) | Retrospective noncomparator | 300 | FFP mean 2.61 U | No control group |
   Ranucci et al. (2008) [98] | CV surgery | Retrospective noncomparator | 4546 | FFP | No control group |
   Schols et al. (2008) [53] | Surgery (CV, abdominal or spinal bone) | Prospective noncomparator | 51 | FFP mean 780 ml | No control group |
   Spinella et al. (2008) [99] | Trauma | Retrospective noncomparator | 708 | FFP mean 3 U | No control group |
   Stricker et al. (2010) [70] | Surgery (other, paediatric) | Retrospective noncomparator | 159 | FFP mean 20 ml/kg | No control group |
   Swisher et al. (1996) [100] | Surgery (oesophageal resection for cancer) | Retrospective noncomparator | 275 | FFP | No control group |
   Tenza et al. (2009) [101] | Liver transplantation | Retrospective noncomparator | 74 | FFP mean 15.7 U | No control group |
   Watson et al. (2009) [103] | Trauma | Retrospective noncomparator | 842 | FFP median 4.8 U | No control group |
   Wiederkehr et al. (2010) [102] | Liver transplantation | Retrospective noncomparator | 155 | FFP | No control group |
Fibrinogen concentrate | |||||
   Bell et al. (2010) [112] | Postpartum haemorrhage | Case series | 6 | Fibrinogen concentrate | No control group |
   Böhrer (1999) [57] | Liver transplantation | Case report | 1 | Fibrinogen concentrate 2 g | No control group |
   Brenni et al. (2010) [58] | Trauma | Case report | 1 | Fibrinogen concentrate 16 g | No control group |
Farriols Danés et al. (2008) [104] | Various | Retrospective noncomparator | 69 | Fibrinogen concentrate median 4 g | No control group |
Fenger-Eriksen et al. (2008) [59] | Severe bleeding | Retrospective noncomparator | 43 | Fibrinogen concentrate mean 2.0 g | No control group |
   Glover et al. (2010) [63] | Postpartum haemorrhage | Case report | 1 | Fibrinogen concentrate | No control group |
   Haas et al. (2008) [113] | Surgery (craniofacial, paediatric) | Case series | 9 | Fibrinogen concentrate median 76 mg/kg | No control group |
   Heindl et al. (2005) [116] | Surgery (other) | Case report | 2 | Fibrinogen concentrate 7 g, 8 g | No control group |
   Innerhofer (2006) [60] | Surgery (lumbar) | Case report | 1 | Fibrinogen concentrate 5 g | No control group |
   Peitsidou et al. (2008) [114] | Emergency caesarean section and Hysterectomy | Case report | 1 | Fibrinogen concentrate 2 g | No control group |
   Schöchl et al. (2010) [61] | Massive trauma, then laparotomy | Case report | 1 | Fibrinogen concentrate 13 g | No control group |
   Schöchl et al. (2010) [62] | Trauma surgery | Case report | 1 | Fibrinogen concentrate 12 g | No control group |
   Schöchl et al. (2010) [73] | Trauma surgery | Retrospective noncomparator | 128 | Fibrinogen concentrate median 7 g | No control group |
   Solomon et al. (2010) [72] | CV surgery | Retrospective noncomparator | 39 | Fibrinogen concentrate mean 6.5 g | No control group |
Thorarinsdottir et al. (2010) [74] | Surgery (various) | Retrospective noncomparator | 37 | Fibrinogen concentrate median 2 g | No control group |
   Weinkove et al. (2008) [115] | Various | Retrospective noncomparator | 30 | Fibrinogen concentrate median 4 g | No control group |
Other | Â | Â | Â | Â | Â |
   Murad et al. (2010) [5] | Various | Meta-analysis | 12,421 | FFP | Various |