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Table 2 Admission and outcome characteristics of the 155 patients admitted with severe metabolic or mixed acidosis treated with buffers or not at day 0

From: Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. a prospective, multiple-center study

Characteristics

Sodium bicarbonate

administration

within first 24 hours of ICU stay

(n= 57)

No sodium bicarbonate

administration

within the first 24 hours of ICU stay

(n= 98)

P value

Age (years)

62 ± 16

64 ± 17

0.26

Admitting diagnosis group

   

   Septic shock

23 (40)

31 (32)

0.30

   Hemorrhagic shock

8 (14)

8 (8)

0.28

   Cardiogenic shock

2 (4)

9 (9)

0.33

   Cardiac arrest

5 (9)

14 (14)

0.45

   Others

19 (33)

36 (37)

0.73

SAPS II upon ICU admission

71 ± 23

64 ± 22

0.10

SOFA upon ICU admission

11 ± 4

10 ± 4

0.15

Vasopressor administration upon ICU admission

49 (86)

81 (83)

0.65

Mechanical ventilation upon ICU admission

30 (52)

54 (55)

0.86

Renal replacement therapy within first 24 hours of ICU stay

15 (26)

16 (17)

0.20

Plasma pH upon ICU admission

7.07 ± 0.15

7.10 ± 0.09

0.39

Bicarbonatemia upon ICU admission (mmol/L)

12.6 ± 5.2

15.4 ± 5.6

< 0.01

PaCO2 upon ICU admission (mmHg)

41.6 ± 12.6

52.1 ± 22.8

< 0.01

Base excess upon ICU admission (mmol/L)

-15.6 ± 6.3

-12.5 ± 5.7

< 0.01

Anion gap corrected upon ICU admission (mmol/L)

31 ± 11

26 ± 8

0.02

Lactatemia upon ICU admission (mmol/L)

9.3 ± 6.9

7.8 ± 5.5

0.32

Length of vasopressor treatment (days)

3.9 ± 4.7

5.3 ± 8.8

0.35

Length of mechanical ventilation (days)

6.6 ± 10.7

8.3 ± 14.0

0.85

ICU length of stay (days)

10.1 ± 15.5

11.4 ± 15.7

0.32

Mortality in the ICU

34 (60)

55 (56)

0.73

  1. PaCO2 = partial pressure of carbon dioxide; SAPS II: Severity Acute Physiology Score II [22]; SOFA = Sequential Organ Failure Assessment [23]. Categorical data are expressed as raw numbers (%). Continuous data are expressed as means ± SD.