Table 4 Logistic regression models with sequential inclusion of each bundle item and in-hospital mortality

1. Lactate measured

1.96

(0.99 to 3.90)

2.03

(1.02 to 4.05)

2.03

(1.02 to 4.05)

2.27

(1.12 to 4.62)

2.38

(1.15 to 4.96)

2.67

(1.24 to 5.75)

2.63

(1.22 to 5.70)

4.06

(1.84 to 8.97)

2. Blood cultures before antibiotics

0.67

(0.29 to 1.54)

0.67

(0.29 to 1.54)

0.68

(0.29 to 1.59)

0.68

(0.29 to 1.59)

0.79

(0.33 to 1.90)

0.78

(0.33 to 1.89)

0.80

(0.33 to 1.94)

3. Antibiotics administered by 3 hours

1.14

(0.30 to 4.38)

1.06

(0.27 to 4.11)

1.09

(0.28 to 4.28)

1.18

(0.26 to 5.28)

1.20

(0.27 to 5.36)

1.35

(0.28 to 6.55)

4. Fluid bolus given

0.50

(0.25 to 0.99)

0.50

(0.25 to 0.99)

0.46

(0.23 to 0.93)

0.45

(0.22 to 0.92)

0.47

(0.23 to 0.96)

5. Achieve CVP >8 mmHg by 6 hours

0.89

(0.57 to 1.37)

1.05

(0.67 to 1.66)

1.01

(0.60 to 1.69)

1.21

(0.71 to 2.06)

6. Achieve MAP >65 mmHg by 6 hours

0.16

(0.06 to 0.44)

0.16

(0.06 to 0.43)

0.20

(0.07 to 0.55)

7. Achieve ScvO₂ >70% by 6 hours

1.10

(0.65 to 1.87)

1.43

(0.82 to 2.51)

8. Lactate clearance

0.32

(0.19 to 0.55)

-2 log-likelihood

531.04

530.18

530.14

526.28

525.98

508.84

508.72

490.73

Change in -2 log-likelihood (χ²)

-

-0.86

-0.04

-3.86

-0.30

-0.05

-0.12

-18.00

Chi-square P value (df = 1)

-

0.35

0.84

0.05

0.58

0.82

0.73

< 0.01