| Model I | Model II | Model III | Model IV | Model V | Model VI | Model VII | Model VIII | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bundle item | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI |
1. Lactate measured | 1.96 | (0.99 to 3.90) | 2.03 | (1.02 to 4.05) | 2.03 | (1.02 to 4.05) | 2.27 | (1.12 to 4.62) | 2.38 | (1.15 to 4.96) | 2.67 | (1.24 to 5.75) | 2.63 | (1.22 to 5.70) | 4.06 | (1.84 to 8.97) |
2. Blood cultures before antibiotics | Â | Â | 0.67 | (0.29 to 1.54) | 0.67 | (0.29 to 1.54) | 0.68 | (0.29 to 1.59) | 0.68 | (0.29 to 1.59) | 0.79 | (0.33 to 1.90) | 0.78 | (0.33 to 1.89) | 0.80 | (0.33 to 1.94) |
3. Antibiotics administered by 3 hours | Â | Â | Â | Â | 1.14 | (0.30 to 4.38) | 1.06 | (0.27 to 4.11) | 1.09 | (0.28 to 4.28) | 1.18 | (0.26 to 5.28) | 1.20 | (0.27 to 5.36) | 1.35 | (0.28 to 6.55) |
4. Fluid bolus given | Â | Â | Â | Â | Â | Â | 0.50 | (0.25 to 0.99) | 0.50 | (0.25 to 0.99) | 0.46 | (0.23 to 0.93) | 0.45 | (0.22 to 0.92) | 0.47 | (0.23 to 0.96) |
5. Achieve CVP >8 mmHg by 6 hours | Â | Â | Â | Â | Â | Â | Â | Â | 0.89 | (0.57 to 1.37) | 1.05 | (0.67 to 1.66) | 1.01 | (0.60 to 1.69) | 1.21 | (0.71 to 2.06) |
6. Achieve MAP >65 mmHg by 6 hours | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.16 | (0.06 to 0.44) | 0.16 | (0.06 to 0.43) | 0.20 | (0.07 to 0.55) |
7. Achieve ScvO2 >70% by 6 hours | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 1.10 | (0.65 to 1.87) | 1.43 | (0.82 to 2.51) |
8. Lactate clearance | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.32 | (0.19 to 0.55) |
-2 log-likelihood | 531.04 | Â | 530.18 | Â | 530.14 | Â | 526.28 | Â | 525.98 | Â | 508.84 | Â | 508.72 | Â | 490.73 | Â |
Change in -2 log-likelihood (χ2) | - |  | -0.86 |  | -0.04 |  | -3.86 |  | -0.30 |  | -0.05 |  | -0.12 |  | -18.00 |  |
Chi-square P value (df = 1) | - | Â | 0.35 | Â | 0.84 | Â | 0.05 | Â | 0.58 | Â | 0.82 | Â | 0.73 | Â | < 0.01 | Â |