Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation

Table 1 Surviving Sepsis Campaign severe sepsis resuscitation bundle

Primary SSC Bundle	1. Lactate measured
	2. Blood cultures before antibiotics
	3. Antibiotics administered by 3 hours
	4. Fluid bolus given
	5. Achieve CVP >8 mmHg by 6 hours
	6. Achieve MAP >65 mmHg by 6 hours
	7. Achieve ScvO₂ >70% by 6 hours
Modified SSC Bundle	Primary SSC Bundle + Lactate clearance

The Primary Surviving Sepsis Campaign (SSC) Bundle includes seven items. The Modified SSC Bundle includes the Primary SSC Bundle and lactate clearance. Lactate clearance is defined as any decrease in lactate within 12 hours from baseline, or an initial lactate <2.0 mmol/l. CVP, central venous pressure; MAP, mean arterial pressure; ScvO₂, central venous oxygen saturation.

ISSN: 1364-8535