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Table 4 Costs, in pounds sterling, of initial hospital episode and readmissions within 4 years

From: Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

  DrotAA, mean (SD) Control, mean (SD)
Overall: two to five organ systems failing   
   Drug cost 5,022 (1,688) 0 (0)
   ICU costs 21,204 (19,660) 10,692 (13,533)
   Hospital costs 5,812 (9,145) 4,411 (7,884)
Total initial episode costs 32,038 (24,285) 15,102 (16,787)
   ICU readmission costs 1,729 (8,252) 1,276 (5,987)
   Hospital costs 2,281 (14,694) 2,054 (11,646)
Total readmission costs 4,010 (21,380) 3,330 (16,057)
Two organ systems failing   
   Drug cost 5,328 (1,338) 0 (0)
   ICU costs 17,364 (15,564) 8,806 (9,142)
   Hospital costs 5,933 (8,889) 4,998 (7,168)
Total initial episode costs 28,625 (19,810) 13,804 (12,108)
   ICU readmission costs 914 (3,941) 916 (3,894)
   Hospital costs 1,652 (5,225) 1,667 (8,538)
Total readmission costs 2,567 (8,202) 2,684 (11,308)
Three to five organ systems failing   
   Drug cost 4,916 (1,773) 0 (0)
   ICU costs 22,853 (20,504) 11,692 (14,921)
   Hospital costs 5,776 (9,496) 3,967 (7,898)
Total initial episode costs 33,544 (25,342) 15,659 (18,311)
   ICU readmission costs 2,152 (9,978) 1,120 (5,604)
   Hospital costs 2,823 (20,799) 1,794 (11,361)
Total readmission costs 4,976 (28,531) 2,914 (15,488)
  1. Overall (two to five organ systems failing): total number = 2,726, Drotrecogin alfa (activated) (DrotAA) = 1,076, control = 1,650; two organ systems failing: total number = 828, DrotAA = 198, control = 630; three to five organ systems failing: total number = 1,898, DrotAA = 878, control = 1,020. ICU, intensive care unit.