Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

Table 4 Costs, in pounds sterling, of initial hospital episode and readmissions within 4 years

	DrotAA, mean (SD)	Control, mean (SD)
Overall: two to five organ systems failing
Drug cost	5,022 (1,688)	0 (0)
ICU costs	21,204 (19,660)	10,692 (13,533)
Hospital costs	5,812 (9,145)	4,411 (7,884)
Total initial episode costs	32,038 (24,285)	15,102 (16,787)
ICU readmission costs	1,729 (8,252)	1,276 (5,987)
Hospital costs	2,281 (14,694)	2,054 (11,646)
Total readmission costs	4,010 (21,380)	3,330 (16,057)
Two organ systems failing
Drug cost	5,328 (1,338)	0 (0)
ICU costs	17,364 (15,564)	8,806 (9,142)
Hospital costs	5,933 (8,889)	4,998 (7,168)
Total initial episode costs	28,625 (19,810)	13,804 (12,108)
ICU readmission costs	914 (3,941)	916 (3,894)
Hospital costs	1,652 (5,225)	1,667 (8,538)
Total readmission costs	2,567 (8,202)	2,684 (11,308)
Three to five organ systems failing
Drug cost	4,916 (1,773)	0 (0)
ICU costs	22,853 (20,504)	11,692 (14,921)
Hospital costs	5,776 (9,496)	3,967 (7,898)
Total initial episode costs	33,544 (25,342)	15,659 (18,311)
ICU readmission costs	2,152 (9,978)	1,120 (5,604)
Hospital costs	2,823 (20,799)	1,794 (11,361)
Total readmission costs	4,976 (28,531)	2,914 (15,488)

Overall (two to five organ systems failing): total number = 2,726, Drotrecogin alfa (activated) (DrotAA) = 1,076, control = 1,650; two organ systems failing: total number = 828, DrotAA = 198, control = 630; three to five organ systems failing: total number = 1,898, DrotAA = 878, control = 1,020. ICU, intensive care unit.

ISSN: 1364-8535