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Table 3 Acute hospital mortality and odds ratios for acute hospital mortality for all patients and for each subgroup before and after Genetic Matching

From: Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

  DrotAA n/N (percentage) Control n/N (percentage) Odds ratio (95% CI) for acute hospital mortality for DrotAA versus control
Overall: two to five organ systems failing    
   Unmatched 490/1,076 (45.54) 817/1,650 (49.52) 0.85 (0.72, 0.98)
   GenMatch 508/1,076 (47.25) 875/1,650 (53.04) 0.79 (0.71, 0.87)
Two organ systems failing    
   Unmatched 80/198 (40.40) 221/630 (35.08) 1.26 (0.81, 1.67)
   GenMatch 93/198 (46.98) 228/630 (36.23) 1.56 (1.25, 1.85)
Three to five organ systems failing    
   Unmatched 410/878 (46.70) 596/1,020 (58.43) 0.62 (0.51, 0.74)
   GenMatch 423/878 (48.16) 616/1,020 (60.38) 0.61 (0.53, 0.69)
  1. CI, confidence interval; DrotAA, Drotrecogin alfa (activated); GenMatch, Genetic Matching.