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Table 2 Patient characteristics before and after Genetic Matching for each subgroup

From: Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

  Mean/percentagea DrotAA Mean/percentagea Control Percent standardized difference
a. Subgroup with two organ systems failing ( n = 198) ( n = 630)  
Age (year)s    
Unmatched 57.58 63.04 26.49
GenMatch 61.76 61.82 0.37
ICNARC model acute physiology score    
Unmatched 22.83 20.44 29.53
GenMatch 20.86 20.88 0.35
Serious conditions in medical history, percentage    
   Cardiovascular    
Unmatched 1.01 1.75 5.40
GenMatch 1.57 1.57 0.00
   Respiratory    
Unmatched 4.55 4.13 1.67
GenMatch 2.78 3.87 2.15
   Renal    
Unmatched 2.02 3.81 9.17
GenMatch 1.09 3.14 5.06
   Liver    
Unmatched 1.52 1.27 1.69
GenMatch 1.33 1.33 0.00
   Immunosuppressed    
Unmatched 7.07 6.98 0.28
GenMatch 4.59 6.16 2.46
ICNARC model predicted probability of acute hospital mortality    
Unmatched 0.42 0.39 10.76
GenMatch 0.39 0.39 0.37
Organ systems failing in first 24 hoursb (percentage) - Cardiovascular/Respiratory    
Unmatched 76.26 66.19 18.61
GenMatch 75.60 69.69 4.70
Mechanical ventilation (percentage)    
Unmatched 88.38 70.16 40.02
GenMatch 75.24 75.12 0.10
b. Subgroup with three to five organ systems failing ( n = 878) ( n = 1,020)  
Age (years)    
Unmatched 58.96 65.16 32.32
GenMatch 62.46 62.47 0.00
ICNARC model acute physiology score    
Unmatched 32.08 27.96 40.83
GenMatch 29.84 29.84 0.01
Serious conditions in medical history (percentage)    
   Cardiovascular    
Unmatched 0.34 1.86 13.58
GenMatch 0.58 1.11 2.04
   Respiratory    
Unmatched 1.60 2.94 7.78
GenMatch 1.42 2.21 2.09
   Renal    
Unmatched 0.91 1.47 4.39
GenMatch 0.90 1.21 1.10
   Liver    
Unmatched 0.68 1.77 8.70
GenMatch 1.16 1.16 0.00
   Immunosuppressed    
Unmatched 7.29 12.75 15.55
GenMatch 6.11 9.80 4.83
ICNARC model predicted probability of acute hospital mortality    
Unmatched 0.64 0.58 20.12
GenMatch 0.61 0.61 0.00
Number of organ systems failing during first 24 hours of stay in critical care (percentage)    
   Three    
Unmatched 49.09 62.94 22.88
GenMatch 54.69 56.74 1.46
   Four    
Unmatched 41.12 29.31 20.07
GenMatch 36.57 34.14 1.79
   Five    
Unmatched 9.80 7.75 5.82
GenMatch 8.75 9.12 0.46
Organ systems failing during first 24 hours of stay in critical careb (percentage)    
   Cardiovascular/Respiratory/Acidosis    
Unmatched 40.77 46.08 8.77
GenMatch 44.10 43.99 0.08
   Cardiovascular/Respiratory/Renal/Acidosis    
Unmatched 31.09 19.90 20.64
GenMatch 25.76 24.97 0.64
Mechanical ventilation on admission or during first 24 hours of stay in critical care (percentage)    
Unmatched 93.39 78.53 38.90
GenMatch 85.51 85.51 0.00
  1. a Mean reported for continuous variable and percentage for categorical variable.
  2. bFor the types of organ failure, results are presented for the most prevalent type for each number of organ failures; results for other types of organ failure are presented in Additional file 1. DrotAA, Drotrecogin alfa (activated); GenMatch, Genetic Matching; ICNARC, Intensive Care National Audit & Research Centre.