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Table 1 Patient characteristics before and after propensity score matching and Genetic Matching

From: Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?

  Mean/percentagea DrotAA (n= 1,076) Mean/percentagea Control (n= 1,650) Percent standardized difference
Age (year)s    
Unmatched 58.70 64.35 28.85
Pscore match 61.48 61.90 2.55
GenMatch 62.22 62.23 0.06
ICNARC model acute physiology score    
Unmatched 30.38 25.09 50.16
Pscore match 27.24 27.18 0.63
GenMatch 27.15 27.15 0.08
Serious conditions in medical history (percentage)    
   Cardiovascular    
Unmatched 0.47 1.82 11.63
Pscore match 1.05 1.39 3.09
GenMatch 1.28 1.28 0.00
   Respiratory    
Unmatched 2.14 3.39 6.50
Pscore match 2.71 3.02 1.85
GenMatch 1.72 2.64 2.22
   Renal    
Unmatched 1.12 2.36 8.31
Pscore match 1.10 1.87 6.33
GenMatch 1.14 1.94 2.32
   Liver    
Unmatched 0.84 1.58 5.84
Pscore match 5.53 1.52 21.88
GenMatch 1.14 1.28 0.47
   Immunosuppressed    
Unmatched 7.25 10.55 9.75
Pscore match 11.35 9.80 5.06
GenMatch 5.61 8.58 4.10
ICNARC model predicted probability of acute hospital mortality    
Unmatched 0.60 0.51 30.31
Pscore match 0.55 0.55 0.21
GenMatch 0.55 0.55 0.06
Number of organ systems failing during first 24 hours of stay in critical care (percentage)    
   Two    
Unmatched 18.40 38.18 38.20
Pscore match 32.15 30.27 4.05
GenMatch 29.35 29.79 0.34
   Three    
Unmatched 40.06 38.91 1.91
Pscore match 37.47 41.22 7.69
GenMatch 38.11 41.16 2.20
   Four    
Unmatched 33.55 18.12 28.31
Pscore match 25.33 21.48 9.10
GenMatch 26.85 22.71 3.40
   Five    
Unmatched 7.99 4.79 10.33
Pscore match 5.05 7.03 8.30
GenMatch 5.69 6.35 0.98
Organ systems failing during first 24 hours of stay in critical careb (percentage)    
   Cardiovascular/Respiratory    
Unmatched 14.03 25.27 24.24
Pscore match 23.38 20.74 6.37
GenMatch 23.51 20.73 2.38
   Cardiovascular/Respiratory/Acidosis    
Unmatched 33.27 28.49 8.41
Pscore match 28.49 32.32 8.33
GenMatch 32.06 32.80 0.55
   Cardiovascular/Respiratory/Renal/Acidosis    
Unmatched 25.37 12.30 26.50
Pscore match 18.50 15.40 8.25
GenMatch 19.15 16.25 2.69
Mechanical ventilation on admission or during first 24 hours of stay in critical care (percentage)    
Unmatched 92.47 75.33 42.51
Pscore match 83.32 82.32 0.93
GenMatch 82.25 82.21 0.03
  1. a Mean reported for continuous variable and percentage for categorical variable
  2. bFor the types of organ failure, results are presented for the most prevalent type for each number of organ failures; results for other types of organ failure are presented in Additional file 1. DrotAA, Drotrecogin alfa (activated); GenMatch, Genetic Matching; ICNARC, Intensive Care National Audit & Research Centre; Pscore, propensity score.