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Table 3 Monocyte human leukocyte antigen-DR expression in peripheral blood mononuclear cells of survivors, nonsurvivors and controls on days 1 and 7

From: Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors

Patient characteristics

Survivors (n= 23)

Nonsurvivors (n= 11)

All patients (n= 34)

Controls (n = 30)

Day 1

    

   Monocytes (%)

11.3 (0.3 to 39.8)

9.2 (2.7 to 40.5)

11.1 (0.3 to 40.5)

3.6 (1.3 to 9.5)

   HLA-DR measurements of positive monocytes (%)

37.8 (1.7 to 66.8)

41.9 (22.3 to 80.7)

41.0 (1.7 to 80.7)

91.7 (57.3 to 98.4)

   HLA-DR measurements (MFI)

0.9 (0.6 to 2.9)

0.8 (0.7 to 1.7)

0.9 (0.6 to 2.9)

1.8 (1.4 to 2.6)

Day 7

(n = 23)

(n = 6)

(n = 29)

 

   Monocytes (%)

9.2 (1.1 to 31.7)

15.6 (3.2 to 25.7)

10.0 (1.1 to 31.7)

 

   HLA-DR measurement of positive monocytes (%)

45.8 (11.4 to 74.9)

33.4 (18.9 to 71.9)

40.6 (11.4 to 74.9)

 

   HLA-DR measurements (MFI)

1.2*(0.7 to 1.7)

0.9 (0.7 to 1.2)

1.1 (0.7 to 1.7)

 
  1. HLA-DR = human leukocyte antigen-DR; PBMC = peripheral blood mononuclear cell; MFI = means of fluorescence intensity. Data are medians (ranges). *P = 0.004 compared with survivors on day 1 by Wilcoxon signed-rank test. P < 0.05 compared with patients with severe sepsis by Mann-Whitney U test.