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Table 2 Caspofungin population pharmacokinetic parameters in plasma

From: Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig

 

Shock group (n= 12)

Control group (n= 16)

Caspofungin parameters

Estimate

RSE (%)

Estimate

RSE (%)

CL (L/hour)

0.21

26

0.29

20

V1 (L)

0.96

45

0.98

24

Q (L/hour)

8.16*

39

4.23

30

V2 (L)

2.8*

15

1.43

12

Vd (L)

3.9*

-

2.5

-

ω (CL) (%)

25

21

75

39

ω (V1) (%)

10

37

80

36

ω (Q) (%)

10

32

54

35

ω (V2) (%)

10

35

19

34

σ (%)

28

13

34

8

  1. CL: central elimination clearance; Q: intercompartmental clearance; RSE: relative standard error;
  2. V1: central volume of distribution; V2: peripheral volume of distribution; Vd: total apparent volume of distribution; σ: residual variability of the model; ω: interindividual variability. *P < 0.05 vs control group.
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Critical Care

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