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Table 1 Caspofungin pharmacokinetic parameters in plasma and lung tissue

From: Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig

 

Shock group (n= 12)

Control group (n= 16)

 

Caspofungin parameters

Median

IQR

Median

IQR

P value

Plasma

     

   Cmax (μg/mL)

21.6

20.7 to 22.3

33.1

28.1 to 38.3

0.002

   AUC0→4 hours (μg/hour/mL)

60.3

58.4 to 66.4

80.8

78.3 to 96.9

0.009

   Cp (μg/mL)

16.1

12.5 to 17.4

20.7

17.4 to 23.1

0.007

Lung tissue

     

   Ct (μg/g)

1.22

0.89 to 1.46

1.64

1.22 to 2.01

0.001

   Ratio (%)

7.76

6.41 to 9.42

7.28

6.2 to 9.5

0.862

  1. AUC0→4 hours: area under the curve of caspofungin plasma concentration from zero to four hours; Cmax: maximum caspofungin concentration; Cp: caspofungin plasma concentration at four hours; Ct: lung caspofungin concentration at four hours; IQR: interquartile range. Ratio = (Ct/Cp) × 100; P values are for shock group vs control group.
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Critical Care

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