Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: a prospective observational trial

Schoen, Julika; Meyerrose, Joscha; Paarmann, Hauke; Heringlake, Matthias; Hueppe, Michael; Berger, Klaus-Ulrich

doi:10.1186/cc10454

Critical Care

Table 3 Characterizing intraoperative and postoperative data in patients with or without postoperative delirium

From: Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: a prospective observational trial

Parameter	Delirium n= 62	Control n= 169	Pvalue
Duration of CPB in minutes, mean (SD)	123.0 (53.2)	118.2 (48.6)	0.519^a
Duration of aortic crossclamp in minutes, mean (SD)	92.8 (40.3)	90.1 (39.3)	0.650^a
Minimal intraoperative hemoglobin in g/L, mean (SD)	80.3 (10.2)	83.2 (10.8)	0.068^a
Intraoperative variables in mL, mean (SD)
Packed red cells	625 (600)	325 (425)	≤ 0.001^a
Fresh frozen plasma	200 (475)	75 (350)	0.107^a
Thrombozytes	50 (150)	25 (125)	0.185^a
Intraoperative cumulative variables in mg, mean (SD)
Dobutamine	37.8 (38.6)	24.5 (35.1)	0.014^a
Norepinephrine	0.96 (1.1)	0.45 (0.7)	0.003 ^a
Milrinone	1.39 (2.0)	0.69 (1.4)	0.011^a
Marker of myocardial injury, mean (SD)
MB fraction of CK percentage on POD 1	5.0 (2.7)	4.7 (2.6)	0.457^a
MB fraction of CK percentage on POD 2	4.0 (3.7)	3.4 (2.7)	0.208^a
MB fraction of CK percentage on POD 3	4.1 (3.4)	3.9 (3.3)	0.629^a
Markers of inflammation, mean (SD)
CRP in mg/dL on POD 1	90.0 (54.8)	83.6 (46.8)	0.483^a
CRP in mg/dL on POD 2	230.2 (60.5)	218.6 (59.4)	0.214^a
CRP in mg/dL on POD 3	219.0 (60.8)	204.4 (65.3)	0.159^a
Leukocytes in μL^-1 on POD 1	10,088 (3,833)	10,335 (3,563)	0.651^a
Leukocytes in μL^-1 on POD 2	11,558 (4,056)	11,358 (3,140)	0.731^a
Leukocytes in μL^-1 on POD 3	10,817 (4,386)	10,179 (2,908)	0.321^a
Marker of renal function, mean (SD)
Creatinine in μmol/L on POD 1	111.6 (91.2)	87.4 (29.1)	0.046^a
Creatinine in μmol/L on POD 2	114.8 (49.7)	91.2 (40.9)	0.002^a
Creatinine in μmol/L on POD 3	111.9 (52.2)	94.7 (48.7)	0.032^a
Renal replacement therapy, number (percentage)
POD 1	4 (6.5)	3 (1.8)	0.068 ^b
POD 2	4 (6.5)	3 (1.8)	0.068^b
POD 3	4 (6.5)	2 (1.2)	0.030^b
Intra-aortic balloon pump, number (percentage)
POD 1	6 (9.7)	3 (1.8)	0.006 ^b
POD 2	4 (6.5)	3 (1.8)	0.068 ^b
POD 3	3 (4.8)	2 (1.2)	0.101^b
Reintubation rate, number (percentage)	4 (6.5)	2 (1.2)	0.026^b
Duration of ventilation in minutes, mean (SD)	1,366 (1,843)	439 (357)	≤ 0.001^a
Intensive care unit length of stay in days, mean (SD)	1.7 (1.4)	0.5 (1.0)	≤ 0.001^a

^aStudent t test; ^bchi-square test. CK, creatin kinase; CPB, cardiopulmonary bypass; CRP, C-reactive protein; MAP, mean arterial pressure; POD, postoperative day; SD, standard deviation.

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