Skip to main content
Figure 3 | Critical Care

Figure 3

From: Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients

Figure 3

Model-predicted effect of 125 mg, 250 mg, 500 mg or 1, 000 mg of acetazolamide. Shown are the effects of acetazolamide (ACET) administered once daily on serum bicarbonate in the presence of (A) low or high levels of serum chloride, (B) coprescription or not of 20 to 160 mg/day furosemide or (C) coprescription or no coprescription of 1 mg/kg/day systemic cortocosteroids. Modelization of ACET pharmacodynamics was derived from 68 chronic obstructive pulmonary disease patients during the weaning period with metabolic alkalosis (Simplified Acute Physiology Score II at ICU admission was standardized at 50 and is shown in all parts of the figure). A higher ACET dosage is required to reduce serum bicarbonate concentrations > 5 mmol/L when high chloride or coprescription of systemic corticosteroids or furosemide occurs.

Back to article page

Critical Care

ISSN: 1364-8535