Figure 1From: Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patientsDifferences between pre-acetazolamide dose bicarbonate level and bicarbonate level at 24 hours in all patients, plotted according to the total dosage of acetazolamide administered. Boxplots show the medians, first and third quartiles and 10th and 90th percentiles. The zero level at predose indicates that these values are based on intrapatient differences (repeated measures). Predose values: median 37.5; 25th and 75th percentiles 34 and 41, respectively; and 10th and 90th percentiles 30 and 45 mmol/L, respectively.Back to article page