Figure 1From: Bench-to-beside review: Acute-on-chronic liver failure - linking the gut, liver and systemic circulationSchematic representation of the presumed pathophysiology of acute-on-chronic liver failure. An acute insult launches a liverdriven cascade of bacterial translocation from the gut, an inappropriate response from the innate immune system, and subsequent intra- and extrahepatic circulatory dysfunction, ultimately leading to multi-organ failure.Back to article page