sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy

Table 3 Univariate and multivariate logistic regression analysis of factors associated with mortality in diabetic and non-diabetics

	Diabetic				Non-diabetic
	Univariate		Multivariate		Univariate		Multivariate
Variable	Estimate	P	Estimate	P	Estimate	P	Estimate	P
Age (years)	0.012	NS			0.036	0.04		NS
Gender	0.464	NS			0.875	NS
BMI	-0.075	NS			-0.083	NS
APACHE II score	0.100	NS			0.124	0.02		NS
SOFA score *	0.345	0.02	0.357	0.03	0.009	NS
sRAGE (pg/ml)	0.0004	NS			-0.00008	NS
IL-6 (pg/ml)	0.00003	NS			0.001	NS
Thrombomodulin (ng/ml)	0.004	NS			0.007	NS
HMGB-1 (ng/ml)	-0.321	NS			0.046	NS
Creatinine (μmol/L)	-0.002	NS			0.003	NS
Creatinine clearance (ml/minute)	-0.0096	NS			-0.028	0.01	-0.058	NS
Blood glucose (mmol/L)*	0.196	NS			0.514	0.003		0.03
PaO₂/FiO₂ (mm Hg)	0.0009	NS			-0.006	NS
INR *	2.753	0.01	2.328	0.04	3.176	0.02		NS

* P < 0.05 for both uni-and multivariate analysis
APACHE, Acute Physiologic Score and Chronic Health Evaluation; HMGB-1, high mobility group box-1; IL-6, interleukin-6; INR, international normalized ratio; PaO₂/FIO₂, ratio of partial pressure of oxygen to the fraction of inspired oxygen; SOFA, Sequential Organ Failure Assessment; sRAGE, soluble receptor for advanced glycation end-products.

ISSN: 1364-8535