Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors

Table 3 Univariable and multivariable analyses of characteristics associated with hospital mortality

Characteristics	Univariable analysis		Multivariable analysis
	Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
Age (per 10-year increase)	1.15 (0.88-1.51)	0.3
Male	2.03 (0.58-7.10)	0.27
HIV risk factor		0.8
MSM	reference
Bisexual	0.78 (0.16-3.82)	0.8
Injecting drug use	0.62 (0.20-1.96)	0.4
Transfusion-related	2.08 (0.18-24.31)	0.6
Heterosexual/other/unknown	1.12 (0.53-2.37)	0.8
HIV-related characteristics
Newly diagnosed HIV infection	1.56 (0.79-3.08)	0.205
Prior HAART at hospital admission	0.78 (0.39-1.57)	0.5
HAART initiated during ICU stay	1.05 (0.32-3.44)	0.9
HAART use in ICU	1.12 (0.56-2.24)	0.7
HIV viral load (per 1-log copies/ml increase)^a	1.025 (0.83-1.26)	0.8
CD4 lymphocyte count (per 10-cells/mm³ decrease)^b	1.033 (1.004-1.063)	0.027	1.036 (1.003-1.069)	0.033
Admission diagnosis
Respiratory failure	0.99 (0.50-1.95)	1.0
Interstitial pneumonitis with ground glass opacity	0.78 (0.39-1.57)	0.5
Sepsis (including bacterial pneumonia)	2.25 (1.08-4.69)	0.03	2.91 (1.11-7.62)	0.029
Hospitalization to ICU admission > 24 hours	2.72 (1.23-6.01)	0.013	2.21 (0.90-5.47)	0.085
Albumin (per 1 g/dl decrease) ^c	1.69 (1.04-2.74)	0.034	1.31 (0.74-2.34)	0.36

The goodness of fit (Hossmer-Lemeshow Chisquare P value) was 0.619. 14 patients were not included in the multivariable model because of missing data.
^aData were available for 121 ICU admissions.
^bData were available for 129 ICU admissions.
^cData were available for 127 ICU admissions.
CI, confidence interval; HAART, highly active antiretroviral therapy; MSM, men who have sex with men.

ISSN: 1364-8535