Figure 1

(a) The effect of bolus doses of L-257 at 0 mg/kg, 3 mg/kg, 30 mg/kg and 300 mg/kg on the mean arterial pressure in the short-term organ function study on anaesthetized Wistar rats ( n = 6 in the each group). The bolus L-257 was given at 0 minutes for 10-minute infusion. Animals treated with 300 mg/kg L-257, x; animals treated with 30 mg/kg L-257, open triangle; animals treated with 3 mg/kg, open square; control animals, solid circle. (b) The initial change of mean arterial pressure 30 minutes after bolus injections among the four groups. *P < 0.05, 30 mg/kg vs. control; ^#P < 0.05, 30 mg/kg vs. 3 mg/kg; ^†P < 0.05, 300 mg/kg vs. control; ^‡P < 0.05, 300 mg/kg vs. 3 m/kg. (c), (d) The effects of bolus doses of L-257 at 0 mg/kg, 3 mg/kg and 30 mg/kg on perfused capillary density and microcirculatory index (n = 4 in each group). *P < 0.05, 30 mg/kg vs. control; ^#P < 0.05, 30 mg/kg vs. 3 m/kg.