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Figure 4 | Critical Care

Figure 4

From: The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis

Figure 4

Effect of circulating microparticle-bound activated protein C (MP-APC) on an endothelial model of apoptosis. Light microscopy (X200 magnification) shows human umbilical vein endothelial cells: [1] untreated, and treated with [2] staurosporine (10 μM), [3] APC + staurosporine, [4] MPs from pre-rhAPC treatment (Day 0), [5] MPs from pre-rhAPC treatment + staurosporine, [6] MPs during rhAPC treatment (Day 4), [7] MPs during rhAPC treatment + staurosporine, [8] MPs during rhAPC treatment + Protein C (PC) Antibody (Ab) + staurosporine, and [9] MPs during rhAPC treatment + antagonist T1 + staurosporine. The bar chart shows corresponding release of up-taken dye with data from six separate experiments expressed as mean ± SD.*P < 0.05 and **P < 0.005 denote significant comparisons to untreated, with significant influences by PC blockade or T1 denoted at base of chart.

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