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Figure 3 | Critical Care

Figure 3

From: The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis

Figure 3

Effect on the differential expression of selected genes by circulating microparticles bearing activated protein C. Human umbilical vein endothelial cells were stimulated with microparticles (MPs) isolated from septic patients before (Day 0) and during (Day 1) recombinant human activated protein C (rhAPC) infusion compared to an equivalent concentration of free APC. Bax, Bcl-x, A20 and KDR genes were analysed by quantitative polymerase chain reaction and expressed relative to untreated cells, which were set at 1. Data from six patients are presented as mean ± SD. *P < 0.05 denotes significant comparisons to untreated, with significant influences by protein C (PC) blockade or antagonist T1 denoted at base of chart.

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